Reactions of Ethers
Ethers (R-O-R’) are compounds formed by replacing hydrogen atoms of an alcohol (R-OH compound) or a phenol (C6H5OH) by an aryl/ acyl group (functional group after removing single hydrogen from an aromatic ring). In this section, reaction, preparation and behavior of ethers are discussed in the context of organic chemistry.
Epoxides
Epoxides are a special class of cyclic ethers which are an important functional group in organic chemistry and generate reactive centers due to their unusual high reactivity. Due to their high reactivity, epoxides are considered to be toxic and mutagenic.
Williamson Ether Synthesis
An organic reaction in which an organohalide and a deprotonated alcohol forms ether is known as Williamson ether synthesis. Alexander Williamson developed the Williamson ether synthesis in 1850. The formation of ether in this synthesis is an SN2 reaction.
Draw the major product for the following substitution reaction and include stereochemistry when appropriate
![**CHEM 201 Homework**
1. **Reaction 1**:
- **Reactants**: Benzyl chloride (aromatic compound with Cl) + Ammonia (NH₂)
- **Reaction Type**: Bimolecular reaction
- **Rate Equation**: Rate = k[substrate][nucleophile]
2. **Reaction 2**:
- **Reactants**: Sodium acetylide ion (negative charge on acetylide carbon) + Methyl iodide (CH₃I)
3. **Reaction 3**:
- **Reactants**:
- Brominated compound (with branched alkyl group)
- Cycloalkyl bromide
- **Products**: Diol
Each step shows important nucleophilic substitution reactions that involve the attack of a nucleophile on an electrophile, demonstrating typical SN2 reaction mechanisms.](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F1b0fb6f0-7854-489d-adf4-53e482a3e72a%2F0cff3011-7a97-4f98-a146-63eb18d1116a%2Fyeedf3_processed.jpeg&w=3840&q=75)
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