Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Transcribed Image Text:### Educational Content: Synthesis Reactions
This section outlines a series of chemical reactions where you are required to determine the major product for each.
---
#### Reaction 1
**Starting Material:**
- Nitro-substituted bicyclo aromatic compound.
**Reagents:**
- \( \text{HNO}_3 \)
- \( \text{H}_2\text{SO}_4 \)
**Description:**
This reaction involves the nitration of an aromatic compound using a mixture of nitric and sulfuric acids. This is a typical electrophilic substitution reaction on the aromatic ring.
---
#### Reaction 2
**Starting Material:**
- Nitro and methoxy-substituted benzene.
**Reagent:**
- Fuming \( \text{H}_2\text{SO}_4 \)
**Description:**
This reaction suggests a sulfonation, which is another type of electrophilic aromatic substitution. The use of fuming sulfuric acid indicates a high concentration of \( \text{SO}_3 \), facilitating the introduction of a sulfonic acid group.
---
#### Reaction 3
**Starting Material:**
- Bicyclic aromatic compound with a chlorine substituent.
**Reagent:**
- \( \text{AlCl}_3 \)
**Description:**
The presence of aluminum chloride indicates a Friedel-Crafts alkylation or acylation. Given that there’s already a chlorine in the compound, the reagent may facilitate a rearrangement or additional substitution.
---
#### Reaction 4
**Steps:**
1. \( \text{EtCOCl / AlCl}_3 \)
2. \( \text{Br}_2, \text{AlBr}_3 \)
3. \( \text{Zn(Hg)}, \text{HCl, heat} \)
4. \( \text{HNO}_3, \text{H}_2\text{SO}_4 \)
**Description:**
This is a multi-step synthesis:
1. **Step 1:** Friedel-Crafts acylation with ethyl carbonyl chloride and aluminum chloride.
2. **Step 2:** Bromination using bromine and aluminum bromide, likely at an activated position.
3. **Step 3:** Clemmensen reduction to remove the carbonyl group and convert it into an alkane.
4. **Step 4:** Nitration with nitric and sulfuric acid.
---
#### Reaction 5
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