Draw the line bond structure for the general form of an amino acid using “R” to represent the side chain. Draw the N- and C- erminus groups using the forms that are predominant at physiological pH (pH = 7.4). Include lone pairs in your drawing. HINT: The structure of the predominant form of an amino acid will depend on the pH because amino acids involve the carboxyl group/carboxylate group conjugate pair and the quaternary ammonium group/amine group conjugate pair. Using the implications of the the Henderson-Hasselbalch relation, summarized in the table below, it is possible to predict the predominant form of these groups at a particular pH. Solution Condition pH pKa pH = pka Relative Amounts of Acid and Base Forms [HA] > [A-] [A-] > [HA] [HA] = [A-] The pK₂ values of amino acid carboxyl groups are between 2 and 5 (depending on which amino acid), therefore, at pH = 7.4, the base form (carboxylate ion) is predominant. Quaternary ammonium groups that are attached to the a-carbons of amino acids have pKą values of about 9.5, therefore, at pH = 7.4, the acid form (quaternary ammonium group) is predominant.

Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
icon
Related questions
icon
Concept explainers
Question
100%

I don't get it at all. Can you help me about the Henderson-Hasselbalch relation, summarized in the table below, it is possible to predict the predominant form of these groups at a particular pH? Draw the line bond structure for the general form of an amino acid using "R" to represent the side chain. Draw the N- and C-terminus groups using the forms that are predominant at physiological pH (pH = 7.4. Include lone pairs in your drawing.

Draw the line bond structure for the general form of an amino acid using "R" to represent the side chain. Draw the N- and C-
terminus groups using the forms that are predominant at physiological pH (pH = 7.4). Include lone pairs in your drawing.
HINT:
The structure of the predominant form of an amino acid will depend on the pH because amino acids
involve the carboxyl group/carboxylate group conjugate pair and the quaternary ammonium
group/amine group conjugate pair. Using the implications of the the Henderson-Hasselbalch
relation, summarized in the table below, it is possible to predict the predominant form of these
groups at a particular pH.
Solution
Condition
pH <pka
pH > pKa
pH = pka
Relative Amounts of
Acid and Base Forms
[HA] > [A]
[A-] > [HA]
[HA] = [A-]
The pK₂ values of amino acid carboxyl groups are between 2 and 5 (depending on which amino
acid), therefore, at pH = 7.4, the base form (carboxylate ion) is predominant.
a
Quaternary ammonium groups that are attached to the a-carbons of amino acids have pK, values of
about 9.5, therefore, at pH = 7.4, the acid form (quaternary ammonium group) is predominant.
Transcribed Image Text:Draw the line bond structure for the general form of an amino acid using "R" to represent the side chain. Draw the N- and C- terminus groups using the forms that are predominant at physiological pH (pH = 7.4). Include lone pairs in your drawing. HINT: The structure of the predominant form of an amino acid will depend on the pH because amino acids involve the carboxyl group/carboxylate group conjugate pair and the quaternary ammonium group/amine group conjugate pair. Using the implications of the the Henderson-Hasselbalch relation, summarized in the table below, it is possible to predict the predominant form of these groups at a particular pH. Solution Condition pH <pka pH > pKa pH = pka Relative Amounts of Acid and Base Forms [HA] > [A] [A-] > [HA] [HA] = [A-] The pK₂ values of amino acid carboxyl groups are between 2 and 5 (depending on which amino acid), therefore, at pH = 7.4, the base form (carboxylate ion) is predominant. a Quaternary ammonium groups that are attached to the a-carbons of amino acids have pK, values of about 9.5, therefore, at pH = 7.4, the acid form (quaternary ammonium group) is predominant.
13.2) Draw the line bond structure for the general form of an amino acid using "R" to represent the side chain. Draw the N- and C-
terminus groups using the forms that are predominant at physiological pH (pH = 7.4). Include lone pairs in your drawing.
quaternary ammonium group
Quaternary ammonium groups that are
attached to the a-carbons of amino
a
acids have pKą values of about 9.5,
therefore, at pH = 7.4, the acid form
(quaternary ammonium group) is
predominant.
ANSWER:
H
H
I. I
+
H-N-C
|
H
R
:0:
||
C-O:
carboxylate group
a
The pK₂ values of amino acid
carboxyl groups are between 2 and 5
(depending on which amino acid),
therefore, at pH = 7.4, the base form
(carboxylate ion) is predominant.
R-group
(called "side-chain")
Transcribed Image Text:13.2) Draw the line bond structure for the general form of an amino acid using "R" to represent the side chain. Draw the N- and C- terminus groups using the forms that are predominant at physiological pH (pH = 7.4). Include lone pairs in your drawing. quaternary ammonium group Quaternary ammonium groups that are attached to the a-carbons of amino a acids have pKą values of about 9.5, therefore, at pH = 7.4, the acid form (quaternary ammonium group) is predominant. ANSWER: H H I. I + H-N-C | H R :0: || C-O: carboxylate group a The pK₂ values of amino acid carboxyl groups are between 2 and 5 (depending on which amino acid), therefore, at pH = 7.4, the base form (carboxylate ion) is predominant. R-group (called "side-chain")
Expert Solution
steps

Step by step

Solved in 3 steps with 3 images

Blurred answer
Knowledge Booster
Lipids
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, chemistry and related others by exploring similar questions and additional content below.
Similar questions
  • SEE MORE QUESTIONS
Recommended textbooks for you
Chemistry
Chemistry
Chemistry
ISBN:
9781305957404
Author:
Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:
Cengage Learning
Chemistry
Chemistry
Chemistry
ISBN:
9781259911156
Author:
Raymond Chang Dr., Jason Overby Professor
Publisher:
McGraw-Hill Education
Principles of Instrumental Analysis
Principles of Instrumental Analysis
Chemistry
ISBN:
9781305577213
Author:
Douglas A. Skoog, F. James Holler, Stanley R. Crouch
Publisher:
Cengage Learning
Organic Chemistry
Organic Chemistry
Chemistry
ISBN:
9780078021558
Author:
Janice Gorzynski Smith Dr.
Publisher:
McGraw-Hill Education
Chemistry: Principles and Reactions
Chemistry: Principles and Reactions
Chemistry
ISBN:
9781305079373
Author:
William L. Masterton, Cecile N. Hurley
Publisher:
Cengage Learning
Elementary Principles of Chemical Processes, Bind…
Elementary Principles of Chemical Processes, Bind…
Chemistry
ISBN:
9781118431221
Author:
Richard M. Felder, Ronald W. Rousseau, Lisa G. Bullard
Publisher:
WILEY