Draw structural formulas for an aldehyde or ketone and alkyl (or aryl) bromide that could be used in a Grignard synthesis of the alcohol shown. OH CH3 I CH3CHCH₂CHCH3 • You do not have to consider stereochemistry. If there is more than one combination, draw only one.
Reactions of Ethers
Ethers (R-O-R’) are compounds formed by replacing hydrogen atoms of an alcohol (R-OH compound) or a phenol (C6H5OH) by an aryl/ acyl group (functional group after removing single hydrogen from an aromatic ring). In this section, reaction, preparation and behavior of ethers are discussed in the context of organic chemistry.
Epoxides
Epoxides are a special class of cyclic ethers which are an important functional group in organic chemistry and generate reactive centers due to their unusual high reactivity. Due to their high reactivity, epoxides are considered to be toxic and mutagenic.
Williamson Ether Synthesis
An organic reaction in which an organohalide and a deprotonated alcohol forms ether is known as Williamson ether synthesis. Alexander Williamson developed the Williamson ether synthesis in 1850. The formation of ether in this synthesis is an SN2 reaction.
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[Review Topics]
[References]
Draw structural formulas for an aldehyde or ketone and alkyl (or aryl) bromide that could be used in a Grignard
synthesis of the alcohol shown.
CH3 OH
CH3CHCH₂CHCH3
• You do not have to consider stereochemistry.
. If there is more than one combination, draw only one.
.
• Draw one structure per sketcher. Add additional sketchers using the drop-down menu in the bottom right
corner.
Separate multiple reactants using the + sign from the drop-down menu.
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