Draw a schematic to represent the process above. Hint: consider which compartments need to be separated and which can be combined. b. Discuss what quantitative information would be required to actually model this system mathematically. a.

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
icon
Related questions
Question
6. From literature, it is known that a drug compartmentalizes in the following way:
1) the drug enters the stomach via a tablet formulation
2) the drug is irreversibly absorbed from the stomach to the plasma
3) the drug is reversibly absorbed into the various tissue compartments,
4) the drug transport to/from the liver shows significantly different behavior than that of the
other tissues.
5) Drug elimination is from the kidneys only.
a. Draw a schematic to represent the process above. Hint: consider which compartments
need to be separated and which can be combined.
b. Discuss what quantitative information would be required to actually model this system
mathematically.
62°F Clear
DELL
Transcribed Image Text:6. From literature, it is known that a drug compartmentalizes in the following way: 1) the drug enters the stomach via a tablet formulation 2) the drug is irreversibly absorbed from the stomach to the plasma 3) the drug is reversibly absorbed into the various tissue compartments, 4) the drug transport to/from the liver shows significantly different behavior than that of the other tissues. 5) Drug elimination is from the kidneys only. a. Draw a schematic to represent the process above. Hint: consider which compartments need to be separated and which can be combined. b. Discuss what quantitative information would be required to actually model this system mathematically. 62°F Clear DELL
4. One specialized type of compartmental model is the Unilateral or Cyclic model (Fig. 2). Apply
your knowledge of compartmental modeling techniques to derive the mass balances for each
compartment.
f1(t)
f2(t)
91
K12
92
K10
V,
V,
K20
f3(t)
K23
K31
93
V3
K30
Figure 2: Schematic of the unilateral model
71:3
9/27/
62°F Clear
DELL
Transcribed Image Text:4. One specialized type of compartmental model is the Unilateral or Cyclic model (Fig. 2). Apply your knowledge of compartmental modeling techniques to derive the mass balances for each compartment. f1(t) f2(t) 91 K12 92 K10 V, V, K20 f3(t) K23 K31 93 V3 K30 Figure 2: Schematic of the unilateral model 71:3 9/27/ 62°F Clear DELL
Expert Solution
trending now

Trending now

This is a popular solution!

steps

Step by step

Solved in 2 steps with 1 images

Blurred answer
Recommended textbooks for you
Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:
9780134580999
Author:
Elaine N. Marieb, Katja N. Hoehn
Publisher:
PEARSON
Biology 2e
Biology 2e
Biology
ISBN:
9781947172517
Author:
Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:
OpenStax
Anatomy & Physiology
Anatomy & Physiology
Biology
ISBN:
9781259398629
Author:
McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:
Mcgraw Hill Education,
Molecular Biology of the Cell (Sixth Edition)
Molecular Biology of the Cell (Sixth Edition)
Biology
ISBN:
9780815344322
Author:
Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher:
W. W. Norton & Company
Laboratory Manual For Human Anatomy & Physiology
Laboratory Manual For Human Anatomy & Physiology
Biology
ISBN:
9781260159363
Author:
Martin, Terry R., Prentice-craver, Cynthia
Publisher:
McGraw-Hill Publishing Co.
Inquiry Into Life (16th Edition)
Inquiry Into Life (16th Edition)
Biology
ISBN:
9781260231700
Author:
Sylvia S. Mader, Michael Windelspecht
Publisher:
McGraw Hill Education