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Curren'S Math For Meds: Dosages & Sol

Curren'S Math For Meds: Dosages & Sol

11th Edition

ISBN:9781305143531

Author:CURREN

Publisher:CURREN

Chapter10: Reconstitution Of Powdered Drugs

Section: Chapter Questions

Problem 4.5P

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Question

6. From literature, it is known that a drug compartmentalizes in the following way:
1) the drug enters the stomach via a tablet formulation
2) the drug is irreversibly absorbed from the stomach to the plasma
3) the drug is reversibly absorbed into the various tissue compartments,
4) the drug transport to/from the liver shows significantly different behavior than that of the
other tissues.
5) Drug elimination is from the kidneys only.
a. Draw a schematic to represent the process above. Hint: consider which compartments
need to be separated and which can be combined.
b. Discuss what quantitative information would be required to actually model this system
mathematically.
62°F Clear
DELL

4. One specialized type of compartmental model is the Unilateral or Cyclic model (Fig. 2). Apply
your knowledge of compartmental modeling techniques to derive the mass balances for each
compartment.
f1(t)
f2(t)
91
K12
92
K10
V,
V,
K20
f3(t)
K23
K31
93
V3
K30
Figure 2: Schematic of the unilateral model
71:3
9/27/
62°F Clear
DELL

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