Down's syndrome, trisomy 21, is due to what likely problem during meiosis? Select one: a. Failure of the APC to add Ub to cohesins, so sister chromatids due not split correctly in anaphase II. b. DNA replication issues causing an additional third chromosome to be replicated. c. Overactive APC adding to many Ub to cohesins, so sister chromatids due not split correctly in anaphase II. d. Failure of the MPF to add Ub to cohesins, so sister chromatids due not split correctly in anaphase II.

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
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Down's syndrome, trisomy 21, is due to what likely problem during meiosis?

Select one:
a. Failure of the APC to add Ub to cohesins, so sister chromatids due not split correctly in anaphase II.
b. DNA replication issues causing an additional third chromosome to be replicated.
c. Overactive APC adding to many Ub to cohesins, so sister chromatids due not split correctly in anaphase II.
d. Failure of the MPF to add Ub to cohesins, so sister chromatids due not split correctly in anaphase II.
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