Double-reciprocal, or Lineweaver-Burk, plots can reveal the type of enzyme inhibition exhibited by an inhibitor. Competitive inhibitors increase the KM without affecting the Vmax -Noncompetitive inhibitors decrease the Vmax without affecting the KM- Uncompetitive inhibitors decrease both the KM and Vmax- 1 V + Inhibitor No inhibitor
Double-reciprocal, or Lineweaver-Burk, plots can reveal the type of enzyme inhibition exhibited by an inhibitor. Competitive inhibitors increase the KM without affecting the Vmax -Noncompetitive inhibitors decrease the Vmax without affecting the KM- Uncompetitive inhibitors decrease both the KM and Vmax- 1 V + Inhibitor No inhibitor
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Q20:
![Double-reciprocal, or Lineweaver-Burk, plots can reveal the type of enzyme inhibition exhibited by an inhibitor. Competitive
inhibitors increase the KM without affecting the Vmax -Noncompetitive inhibitors decrease the Vmax without affecting the KM.
Uncompetitive inhibitors decrease both the KM and Vmax
O competitive
O noncompetitive
-|>
uncompetitive
cannot be determined
+ Inhibitor
No inhibitor
Based on the Lineweaver-Burk plot, what type of enzyme inhibition is exhibited by the inhibitor?
1
[S]](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Fc94cb5d1-997a-49d0-b0ef-9ec02bf0a187%2Ff3e91f73-647b-46cd-b341-9458e7712264%2F8yersdb_processed.png&w=3840&q=75)
Transcribed Image Text:Double-reciprocal, or Lineweaver-Burk, plots can reveal the type of enzyme inhibition exhibited by an inhibitor. Competitive
inhibitors increase the KM without affecting the Vmax -Noncompetitive inhibitors decrease the Vmax without affecting the KM.
Uncompetitive inhibitors decrease both the KM and Vmax
O competitive
O noncompetitive
-|>
uncompetitive
cannot be determined
+ Inhibitor
No inhibitor
Based on the Lineweaver-Burk plot, what type of enzyme inhibition is exhibited by the inhibitor?
1
[S]
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