Do the fasting plasma glucose and glycosylated hemoglobin match? Why or why not?

Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
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Do the fasting plasma glucose and glycosylated hemoglobin match? Why or why not?

reagents, which contain an alkaline solution of
cupric ions stabilized by citrate or tartrate, respec-
tively, have been used to detect reducing agents in
urine and other body fluids. Another chemical char-
acteristic that used to be exploited to quantitate
carbohydrates is the ability of these molecules to
form Schiff bases with aromatic amines. O-toluidine
in a hot acidic solution will yield a colored compound
with an absorbance maximum at 630 nm. Galactose,
an aldohexose, and mannose, an aldopentose, will
also react with O-toluidine and produce a colored
compound that can interfere with the reaction. The
Schiff base reaction with O-toluidine is of historical
interest only and has been replaced by more specific
CASE STUDY 9.8, PART 2
Recall Alfred. He admits he does not always eat a healthy diet, especially when he travels with
utive quarters, a fa ing glucose and glycosylated hemoglobin were
performed to monitor his disease. The results are as follows:
his
For three
Plasma glucose, fasting
Glycosylated hemoglobin
Quarter 1
280 mg/dL
7.8%
the Trinder reac
the
pling reaction used in the glucose
is subject to positive and nega
Increased levels of uric acid, biliru
acid can cause falsely decreased
of these substances being oxidize
which then prevents the oxidation
the chromogen. Strong oxidizing s
bleach, can cause falsely increased.
consumption electrode can be us
direct measurement of oxygen by
technique, which avoids this in
depletion is measured and is
amount of glucose present. Pol
Quarter 2
85 mg/dL
15.3%
Quarter 3
91 mg/dL
8.5%
1.
In which quarter was the patient's glucose best controlled? The least controlled?
2. Do the fasting plasma glucose and glycosylated hemoglobin match? Why or why not?
3. What methods are used to measure glycosylated hemoglobin?
4. What potential conditions might cause erroneous results?
Transcribed Image Text:reagents, which contain an alkaline solution of cupric ions stabilized by citrate or tartrate, respec- tively, have been used to detect reducing agents in urine and other body fluids. Another chemical char- acteristic that used to be exploited to quantitate carbohydrates is the ability of these molecules to form Schiff bases with aromatic amines. O-toluidine in a hot acidic solution will yield a colored compound with an absorbance maximum at 630 nm. Galactose, an aldohexose, and mannose, an aldopentose, will also react with O-toluidine and produce a colored compound that can interfere with the reaction. The Schiff base reaction with O-toluidine is of historical interest only and has been replaced by more specific CASE STUDY 9.8, PART 2 Recall Alfred. He admits he does not always eat a healthy diet, especially when he travels with utive quarters, a fa ing glucose and glycosylated hemoglobin were performed to monitor his disease. The results are as follows: his For three Plasma glucose, fasting Glycosylated hemoglobin Quarter 1 280 mg/dL 7.8% the Trinder reac the pling reaction used in the glucose is subject to positive and nega Increased levels of uric acid, biliru acid can cause falsely decreased of these substances being oxidize which then prevents the oxidation the chromogen. Strong oxidizing s bleach, can cause falsely increased. consumption electrode can be us direct measurement of oxygen by technique, which avoids this in depletion is measured and is amount of glucose present. Pol Quarter 2 85 mg/dL 15.3% Quarter 3 91 mg/dL 8.5% 1. In which quarter was the patient's glucose best controlled? The least controlled? 2. Do the fasting plasma glucose and glycosylated hemoglobin match? Why or why not? 3. What methods are used to measure glycosylated hemoglobin? 4. What potential conditions might cause erroneous results?
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