21 Disease ControlgroupgroupAllele A 25,35024,133Allele C 24,650 25,867SNP1SNP 2; risk allele is CSNP 3; risk allele is GSNP 2; risk allele is TSNP 3; risk allele is ASNP 1; risk allele is ASNP2SNP 1; risk allele is CAllele CAllele TResults are shown above for 3 biallelic SNPs on the same chromosome used in aGWAS examining SNP-trait correlations for a complex human disease trait. Tableentries show the number of people with the indicated SNP allele that have thedisease (disease group) or don't have the disease (control group). Which SNPwould have the highest -log₁0(p-value) score in a Manhattan plot summarizingresults of this GWAS, and which is the SNP "risk allele"?Disease Controlgroupgroup1,4201,50948,580 48,491SNP3Allele GAllele ADiseasegroup47,3602,640Controlgroup3,10946,891

Answered: Disease Control group group Allele A…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

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Disease Control
group
group
Allele A 25,350
24,133
Allele C 24,650 25,867
SNP1
SNP 2; risk allele is C
SNP 3; risk allele is G
SNP 2; risk allele is T
SNP 3; risk allele is A
SNP 1; risk allele is A
SNP2
SNP 1; risk allele is C
Allele C
Allele T
Results are shown above for 3 biallelic SNPs on the same chromosome used in a
GWAS examining SNP-trait correlations for a complex human disease trait. Table
entries show the number of people with the indicated SNP allele that have the
disease (disease group) or don't have the disease (control group). Which SNP
would have the highest -log₁0(p-value) score in a Manhattan plot summarizing
results of this GWAS, and which is the SNP "risk allele"?
Disease Control
group
group
1,420
1,509
48,580 48,491
SNP3
Allele G
Allele A
Disease
group
47,360
2,640
Control
group
3,109
46,891

Expert Solution

Step 1: About GWAS

In a Genome-Wide Association Study (GWAS), the -log10(p-value) score for each SNP (Single Nucleotide Polymorphism) measures its statistical significance in association with a particular disease trait. The higher the -log10(p-value) score, the more significant the association between the SNP and the disease.

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