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- Briefly explain the role of acetlycholinesterase inhibitors in impulse transmission processDescribe the major characteristics and actions of antihistamines. What is a difference between first and second generation of antihistamines?How does ligand binding, and voltage changes regulate specific types of ion channels? Provide examples of different drugs action on such targets by giving discussing briefly their mechanism of action.
- What is the role of beta blockers when treating certain types of visceral diseases?Give an overview of the pathway and what it does, and explain the nature of the TNF ligand and the receptor for that ligand. Make sure to include an explanation of the proteolytic and phosphorylation cascades.Why might a person who is gravely ill not want to participate in a placebo-controlled drug study?
- Discuss the SARs of 4 selective Beta Blockers and 1 combined beta blockers.Name 5 drugs that have a high binding affinity towards the D2 receptorE: Using either GPCRs (G-protein couples receptors) or RTKs (Receptor tyrosine kinases), describe: 1. How ligand binding activates the receptor. Ex: which proteins are involved? what changes can occur to the receptor after binding the ligand? 2. A signal transduction pathway that occurs due to the ligand binding (must include a secondary messenger). 3. Any cellular response due to the ligand binding. 4. A way that the signal pathway is regulated.
- describe the outcome of EGFR inhibition as well as the differences between erlotinib and panitumumab’s mechanisms of action. EGFR- driven cancer cells can become resistant to tyrosine kinase inhibitors. Explain the two types of EGFR blockade acquired resistance and propose a subsequent treatment option.Please explain why it's true or falseDescribe the mechanism of action of antiretrovirals?