Discuss the rational for the use of Sulfonamide (Sufa drug) as an antimicrobial agent.
The rationale for the use of sulfonamide as an antimicrobial agent -The sulfonamides are a gathering of manufactured antimicrobial specialists that are primary analogs of para-aminobenzoic acid (PABA). They are competitive inhibitors of folic acid metabolism. The sulfonamides are very much retained orally and discharged chiefly in the pee. While they were initially expansive range specialists, a lot of opposition has been created to them during the beyond 60 years of utilization. Today sulfonamides are ordinarily utilized in blend with other antimicrobial specialists. As monotherapy, they are utilized for the most part to treat basic, acute urinary lot diseases. Incidental effects include hypersensitivity reactions and alterations of the hematopoietic framework. Although renal damage due to testimony in the kidney of medication precious stones was normal with the less dissolvable sulfonamides, more up to date, more solvent specialists are less inclined to encourage.
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