11 The diagram shown represents the coding strand of the myosin gene. Mutations in myosin can lead to muscle defects during development. Using what you know about how mutations canaffect transcriptional and post-transcriptional regulation, match the results shown on the Northern (mature mRNA) to the mutations shown. The N lane shows the size and amount expectedfor non-mutated myosin mRNA. All samples were loaded at the top (-) side of the gel.Part 1. Which lane or lanes on the gel could be the result of mutation A?ТАТААAUGUAAOnly knownregulatoryregionTSSMutation B:Mutation C.20 nucleotides3 nucleotidesA: 5-basedeletiondeletedchangedN 1 2 3 4 5+lane 1lane 2lane 3lane 4lane 5O O 0 0

Name: 11 The diagram shown represents the coding strand of the myosin gene.
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Description: 11 The diagram shown represents the coding strand of the myosin gene. Mutations in myosin can lead to muscle defects during development. Using what you know about how mutations canaffect transcriptional and post-transcriptional regulation, match the

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Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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The diagram shown represents the coding strand of the myosin gene. Mutations in myosin can lead to muscle defects during development. Using what you know about how mutations can
affect transcriptional and post-transcriptional regulation, match the results shown on the Northern (mature mRNA) to the mutations shown. The N lane shows the size and amount expected
for non-mutated myosin mRNA. All samples were loaded at the top (-) side of the gel.
Part 1. Which lane or lanes on the gel could be the result of mutation A?
ТАТАА
AUG
UAA
Only known
regulatory
region
TSS
Mutation B:
Mutation C.
20 nucleotides
3 nucleotides
A: 5-base
deletion
deleted
changed
N 1 2 3 4 5
+
lane 1
lane 2
lane 3
lane 4
lane 5
O O 0 0

Expert Solution

Step 1

The correct answer is Option E - LANE 5

Explanation

The regulatory region of a gene is a sequence of nucleotide bases which are upstream from the gene. These are essentially DNA sequences which are recognized by enzyme RNA polymerase. Thereon, the enzyme attaches itself to the regulatory sequence, along with accessory transcription factors. The end results is the synthesis of mRNA (transcription).

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