Describe with a suitable example why the characterisation of chiral compounds is important to the pharmaceutical industry and indicate why separation of the enantiomers can prove challenging. Explain how capillary electophoresis can be used in the analysis of these compounds.

Describe with a suitable example why the characterisation of chiral compounds is important to the pharmaceutical industry and indicate why separation of the enantiomers can prove challenging. Explain how capillary electophoresis can be used in the analysis of these compounds.

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

See similar textbooks

Related questions

Q: Would you expect transcontinental transport (i.e., transport across Canada from the Pacific coast to…

A: In order to ship a chemical from one region to another, it is necessary to understand the properties…

Q: Chemistry The chirality center and four adjacent atoms have been extracted from Thalidomide to give…

A: #2: First, we have to draw two identical models of the given molecule and placed side by side in…

Q: A compound with formula C6H14O gave the following HNMR: 1.17 ppm, t, 3H 1.20 ppm, s , 9H 3.42 ppm,…

A: The spectroscopy technique of nuclear magnetic resonance (NMR) is extremely useful for the study of…

Q: PK, = 9.87 H н н → Glycine O-H PK = 2.35

A: We know if the pH is greater than pka, then deprotonation occurs and it exists in deprotonated form.…

Q: Explain the process of Calculating Enantiomeric Excess ?

A: The absolute difference between the mole fraction of two enantiomers is termed as enantiomers.

Q: Which technique below would best complement a study of biomolecule structure using homology…

A: Given: Study of biomolecules strictures using homology modelling To find: Best techniques for it.…

Q: 15. A simulation using the polarizable continuum model (PCM) predicts that the carbonyl stretching…

A: In the given question we have to predict the bond length on the basis of the given stretching…

Q: Answer ALL parts of this question. The structure shown below is that of one of the optical isomers…

A: Ibuprofen is a non-steroidal anti-inflammatory drug . It reduces the inflammation and pain causing…

Q: (a) The two most acidic hydrogens of uracil have pKa’s of 9.5 and 14.2, respectively. Match these…

A: The acid dissociation constant (Ka) is the measure of the acidity of a substance. pKa is defined as…

Q: Give reasons for the following:(i) Aniline does not undergo Friedal-Crafts reaction.(ii) (CH3)2 NH…

A: Friedal-Crafts reaction is an electrophillic substitution of aromatic ring with an alkyl halide and…

Q: 5) For the formula of C5H12O, (a) show your calculation and determine the degrees of unsaturation…

A: DBE for the molecular formula CxHyOz can be calculated by using the formula below.DBE = x + 1 -…

Q: How would the pKa values of carboxylicacids, alcohols, ammonium ions 1RNH32 + , phenol, and an…

A: The strength of a chemical substance acidity is determined by its pKa value.

Q: categorize each pair of structures using all the terms that apply: not isomers, structural isomers,…

A: All the structures are categorized below-

Q: Compound A is a branched-chain alcohol that undergoes oxidation to produce compound B. Compound B is…

A: Compound A is a branched-chain alcohol that undergoes oxidation to produce compound B. Compound B is…

Q: Which of the following molecules is/are chiral?

A: If a molecule has a chiral carbon, then it may or may not be a chiral molecule. The best way to…

Q: Can facial and meridional isomers be chiral? justify

A: We have to show facial and meridional isomers to be chiral? We know if there is no plane of…

Q: A new chemical reaction produced a mixture of two enantiomers. When 9.0 g of this mixture was…

A: The percentage of (+) and (-) enantiomers produced in the reaction is to be found out. For this the…

Q: Calculate the reduced masses of 13C160 and 12C180 isotopologues, and find the corresponding…

A: Reduced Masses:13C16O:Reduced mass (μ) = (mC * mO) / (mC + mO)μ = (13.0 amu * 16.0 amu) / (13.0 amu…

Q: What factors do you have to consider when differentiating the relative strength of the IMF’s in…

A: Step 1:Methanol, ethanol, propanol, and butanol are all alcohols. They contain a hydroxyl functional…

Q: What is the function of a chromophore and an auxochrome in the development of colour in an organic…

A: A chromophore is the part of a molecule responsible for showing its color. The color that is seen by…

Q: You have a Compound A which over time decomposes into Compound B. By performing a UV-Vis test at a…

A: According to lambert's beer law ---------- A = - logTε × c × l = - logT where A is the absorbance,…

Q: Account for the following :(i) Primary amines (R-NH2) have higher boiling point than tertiary amines…

A: (i) Primary amines have hydrogens which can participate in intermolecular hydrogen bonding where…

Q: Discuss peak splitting, and draw H(proton) NMR spectra for CH3CH2CH2F structure, label and explain…

A: For the above given molecule, presence of F atom play a key role for deciding the nature of the…

Q: Discuss the meaning of the term chirality in organic chemistry? Include in your discussion the…

A: Chirality is a term used in organic chemistry to describe the property of a molecule that is…

Q: The coordinates of the atoms of an ethanoic acid dimer are set out in more detail as shown. Consider…

A: Ethanoic acid contains -OH group. This alcoholic group makes hydrogen bonding with the another…

Q: What is the dominant charge on the side group of Cys at pH = 7? (Note: The pl for Cys is 5.07.)

A: To determine the charge on a side chain at a given pH using the isoelectric point (pI) value, we…

Q: Deduce the structure of compound A C9H1002 , Amax= 253 cm-1 , IR bands,3035, 2960, 2870, 1680, 1610,…

Q: 3. There is a class of polyesters that have the general structure shown below. . For example, in…

A: The equation which relates the number average molecular weight and glass transition temperature is…

Q: Give a single benefit for each polymerisation from carrying them out under a nitrogen atmosphere?…

A: Introduction: The polydispersity index (PDI) is dependent on the two parameters, i.e (I) number…

Q: Illustrate clearly, with aid of at least three distinct examples, the impact hat chirality can have…

A: Compounds that have mirror-image pairs are known as chiral. The drugs which have this chiral…

Q: Calculate unperturbed equilibrium radius of gyration, Rg, of polypropylene with molecular weight…

A: Given compound:

Q: Why is it necessary to resolve Chiral pharmaceuticals why can't we just use racemic versions in the…

A: The separation of the components of a racemic mixture is called chiral resolution. It is helpful for…

Q: (i) Dihedral potentials for ethane and biphenyl are shown below. 180 Dihedral angle / degrees 90 270…

A: The dihedral potential is given by , VDA = Vn21+Cosn∅-∅° , where, VDA = Dihedral potential…

Q: Give the systematic name for each of the followingcompounds:(a) Cu2S and CuS (b)…

A: Since you have posted a question with multiple parts, we will solve first three subparts for you. To…

Q: While (S)-ibuprofen is the active ingredient, commercial ibuprofen is sold as a racemic drug because…

A: The research's lab product contains 94 % enantiomeric excess of the S product. Therefore, the…

Q: Can you give an example of homotopic, heterotopic, enantiotopic, and diastereotopic for compounds?

A: Topicity is the stereochemical relationship between substituents and the structure to which they are…

Q: For the formula C6H₁4, calculate the index of hydrogen deficiency (IHD) and select all the types of…

A: We have to calculate the IHD and predict correct option.

Q: 3. Deduce the structure of the molecule with the formula CaHuo with adsorption in the FTIR spectrum…

A: In this question, we have given the values of infrared spectroscopy and NMR spectroscopy. We have to…

Q: An aqueous solution containing 6.67 g of an optically-pure compound was diluted to 7.00 x 10² mL…

A: The specific rotation of a compound is expressed as αc.l ......(1) Where, α = observed angle in…

Q: QUESTION I Identify the functional groups numbered (i) -(x) in the molecule below (vu) N. N (v)…

A: The Functional groups of the compound with functional group from (i) to (ix) And the enantiomers…

Q: Write out a scheme for the resolution of the two enantiomers of the antiplatelet drug clopidogrel…

A: The stereogenic center of clopidogrel and 10-camphorsulfonic acid are shown in figure 1.

Q: What is the requirement for a molecule to be active in the Infra Red region?

A: Requirement for molecule to be active in the Infra Red region:

Q: An unknown sugar is known to equilibrate between two forms, I and II, in aqueous solution. This…

A: When species I was dissolved in pure water and the optical rotation was measured, it gave aspecific…

Q: NH2 OH NEN: `NH2 IZ IZ

A: Aniline reaction with nitrous acid(HNO2) to form diazonium salt.

Question

Expert Solution

This question has been solved!

Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.

SEE SOLUTION Check out a sample Q&A here

Step by step

Solved in 2 steps

SEE SOLUTION Check out a sample Q&A here

Similar questions

c) An unknown chiral organic compound with molecular formula C7H1402 has a characteristic IR absorptions at approximately 3000 cm1, 1715 cm1, 2400 - 3400 cm-1 (broad absorption) and 1250 cm1. Propose a possible structure of this unknown compound.
Briefly discuss the significance of hyperconjugation, tautamerism and inductive effect.
The proton resonance of the OH group is found at δ 5.80 for phenol and at δ 10.67 for 2- nitrophenol, both in dilute solution of deuterated chloroform CDCl3 . Explain.
Acrolein (CH2=CH-CHO) shows two bands , at 210 nm (11,500) and 315 nm (15) . Assign these bands.
Chemistry 17.37 For the following compounds, give the systematic name. CH2CH3 (a) H (b) C-OCH3 (c) OCH,CH3 CH2CH3 (а) Н—С—N CH,CH3
as far as i know all the chiral molecule can be used to carry out optical resolution. so i think material C also can be an option but the answer says only E can be used. could you explain why not C? Please answer very soon will give rating surely
(c) Answer the following questions: It is possible for a compound to be chiral even though it lacks a carbon atom with four different groups. Using two nitro groups, one isopropyl group and one carboxy group as substituents, draw the structure of an optically active biphenyl that is void of a chiral carbon. i. ii. Deduce, giving reasons, whether or not the following molecules are optically active. H3C CH3 ČH(CH3)2 Quaternary ammonium salt NH2 Compound A НОСІНС OCH3 OCH3 Br Compound B
Draw a pentapeptide, peptide sequence: IENAP Show the position of all 'heavy' atoms with the appropriate letter (C, N, O, S etc.) and indicate the number of attached hydrogen atoms (no skeletal structures allowed).- Show the chirality of the alpha carbon of every residue as the L isomer (not required for Glycine). All trigonal planar groups must be shown explicitly with appropriate geometry. • Show all double bonds and/or partial double bonds. • Draw all ionisable groups as their most highly populated state at pH 7.4 Make the peptide bond between the fourth residue and proline the cis isomer.- Show all other peptide bonds as trans.e
Give handwritten answer
4. a) Mention and describe the first method used for the synthesis of carbon nanotubes? (4) b) Numerous nanomaterials have been synthesized using Chemical Vapour Deposition (CVD) method. Mention five step mechanism that are involved in CVD process? (5) c) Describe and compare FTIR and Raman spectroscopy d) Discuss how the optical properties are measured using UV-VIS
Identify monomeric and multimeric (di-,tri-meric, for example) saccharides from this group. If you come across multimeric polypeptides, state the mono- mers that form these multimers. State the nature of the bond that links two units together in each case. (a) Maltose (b) Trehalose (c) Lactose (d) Sucrose (e) Cellobiose (f) Agarose
A) Considering compounds 2a through 2l, identify: 1)one pair of geometric isomers 2)two pairs of enantiomers and 3)three pairs of identical molecules B) Give the names, including the configurations, of each of the geometric isomers and of each of the enantiomers identified in 1A and 1B. Draw the relevant structures. C) Sort compounds 2a, 2b, 2c, 2f and 2k in order of increasing solubility in water and briefly justify.