describe the role of mitochondria in initiating apoptosis. please describe and summarize in short two paragraphs only.
describe the role of mitochondria in initiating apoptosis. please describe and summarize in short two paragraphs only.
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Question
describe the role of mitochondria in initiating apoptosis. please describe and summarize in short two paragraphs only.

Transcribed Image Text:The Mitochondria
Play an Initiating
Role in Apoptosis
DNA
damage
Cytochrome c
Apaf-1 (apoptosis
protease activating
factor-1)
Procaspase-9
monomers
(inactive)
Stress
Procaspase-3
Procaspase-7
MK
ATP
Apoptosome causes dimer-
ization of procaspase-9,
creating active caspase-9
dimers.
ROS Developmental
signal
Permeability transition
pore complex opens.
Cytochromec
moves to cytosol.
Binding of cytochrome c
and ATP induces Apaf-1 to
form an apoptosome.
Apoptosome
Caspase-9
dimers
(active)
Caspase-9 catalyzes
proteolytic activation
of caspase-3 and
caspase-7.
These caspases lead to death
and reabsorption of the cell.
Caspase-3
Caspase-7
Cell death
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