Describe the role of mitochondria in initiating apoptosis?   Please answer the question according to the picture. please answer one short paragraph only. if you can make it in bullet points that would be great. please only short answer including points stated in the attached slide.

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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 Describe the role of mitochondria in initiating apoptosis?

 

Please answer the question according to the picture.

please answer one short paragraph only. if you can make it in bullet points that would be great.

please only short answer including points stated in the attached slide.

 

The Mitochondria
Play an Initiating
Role in Apoptosis
DNA
damage
Cytochrome c
Apaf-1 (apoptosis
protease activating
factor-1)
Procaspase-9
monomers
(inactive)
Stress
Me
ATP
Apoptosome causes dimer-
ization of procaspase-9,
creating active caspase-9
dimers.
ROS Developmental
signal
Permeability transition
pore complex opens.
Procaspase-3
Procaspase-7 caspase-7.
Cytochrome c
moves to cytosol.
Binding of cytochrome c
and ATP induces Apaf-1 to
form an apoptosome.
Apoptosome
Caspase-9 catalyzes
proteolytic activation
of caspase-3 and
Caspase-9
dimers
(active)
These caspases lead to death
and reabsorption of the cell.
Caspase-3
Caspase-7
Cell death
Transcribed Image Text:The Mitochondria Play an Initiating Role in Apoptosis DNA damage Cytochrome c Apaf-1 (apoptosis protease activating factor-1) Procaspase-9 monomers (inactive) Stress Me ATP Apoptosome causes dimer- ization of procaspase-9, creating active caspase-9 dimers. ROS Developmental signal Permeability transition pore complex opens. Procaspase-3 Procaspase-7 caspase-7. Cytochrome c moves to cytosol. Binding of cytochrome c and ATP induces Apaf-1 to form an apoptosome. Apoptosome Caspase-9 catalyzes proteolytic activation of caspase-3 and Caspase-9 dimers (active) These caspases lead to death and reabsorption of the cell. Caspase-3 Caspase-7 Cell death
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