- Describe the consequences of frame shift mutation.
The mutation in which insertion or deletion of the nucleotide takes place is called frameshift mutation. It is called a frameshift mutation because the shifting of the reading frame will occur. Various diseases are caused due to frameshift mutation like cystic fibrosis, different forms of cancer, Crohn's disease.
A frameshift mutation is a form of mutation which will occur during the insertion or deletion of a particular sequence of the DNA that shifts the reading frame sequence. At one time, the reading of three nucleotides occurs in units known as codons. When the usual codon sequence is disturbed because of the insertion or deletion of one or more than one nucleotide, frameshift mutation will occur. For example - if one nucleotide will be deleted in the sequence, then the damage will occur in the full reading frame after the mutation. Hence, the consequence of the frameshift mutation is abnormal protein formation and the sequence of incorrect amino acids, and this abnormal protein can be longer or shorter than the original protein. The Frameshift mutation will result in harmful changes in the polypeptide chain, which will lead to non-functional protein.
Step by step
Solved in 3 steps
