Describe how viral oncotherapy can be used to treat cancer. Be sure to describe what a tumor cell must do to be susceptible to oncotherapy and describe a potential challenge with using the treatment
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Describe how viral oncotherapy can be used to treat cancer. Be sure to describe what a tumor cell must do to be susceptible to oncotherapy and describe a potential challenge with using the treatment.
The first oncolytic virus to be approved by the FDA was talimogene laherparepvec, or T-VEC, a melanoma treatment. The treatment, which is injected into tumours, was designed to produce a protein that stimulates the production of immune cells in the body while also lowering the risk of herpes transmission.
Tumors that could not be injected shrank in some patients who received the therapy, indicating that T-VEC can elicit a systemic immune response.
"The oncolytic virus kills tumour cells while also causing the release of danger signals, which aids in the generation of an immune response."
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