Define the meaning of the term "peptic ulcer disease". Discuss some of the risk factors that make people susceptible (including factors that protect the mucosa of the stomach/duodenum and those that cause damage to it.  ANSWER SHOULD INCLUDE: Accurate definition, e.g. mucosa break greater than 3-5mm in the stomach or duodenum with a visible depth.  Discussion of factors e.g. infections (H. Pylori; others mainly in immunocompromised patients,  e.g. cytomegalovirus ,tuberculosis, and syphilis), gastric bypass surgery,  cigarette smoking, medication/drugs, physiological stress associated with critical illness (e.g. septicaemia), autoimmune diseases, eg, vasculitis, sarcoidosis, Crohn's disease.   Discussion of factors e.g. protection: bucarb, blood flow, prostaglandin, mucus. Damage: H. Pylori,  gastric acid, pepsin, drugs  e.g. NSAID

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