Which of the following statements about cellular DNA metabolism is(are) TRUE?A All DNA polymerases have highi fidelity due to their 3:to-5' exonuclease activityaUracil bases appoar in DNA as a result of deamination of cytidine basesOC DNA primase synthesizes a short RNA primer that later appears at the 5 end of each Okazaki tragment.Do. DNA polymerase adds nucieotides to the 3end of a growing DNA strandDESpecial methyltransferase modifies adenines in GATC sequences of the newly synthesized DNA strands for subsequent re-OR Endonucleases are able to degrade both circular ald linear DNA molecules

Name: Which of the following statements about cellular DNA metabolism is(ar
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Description: Which of the following statements about cellular DNA metabolism is(are) TRUE?A All DNA polymerases have highi fidelity due to their 3:to-5' exonuclease activityaUracil bases appoar in DNA as a result of deamination of cytidine basesOC DNA primase sy

Answered: DaDNA polymerase adds nucieotides to…

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Biology

DaDNA polymerase adds nucieotides to the 3-end of a growing DNA strand

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter11: Genome Alterations: Mutation And Epigenetics

Section: Chapter Questions

Problem 18QP: Replication involves a period of time during which DNA is particularly susceptible to the...

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Replication involves a period of time during which DNA is particularly susceptible to the introduction of mutations. If nucleotides can be incorporated into DNA at a rate of 20 nucleotides/second and the human genome contains 3 billion nucleotides, how long will replication take? How is this time reduced so that replication can take place in a few hours?
You are characterizing a new DNA polymerase. In a test tube, you incubate the enzyme with all the components needed for catalysis, EXCEPT you don't add any dNTPs. However, you notice that some type of catalysis has occurred. What is the most likely product in this case? O The supercoils in the DNA have been relieved O The sugar has been converted from a deoxyribose to a ribose A DNA strand is one base shorter due to nuclease activity The magnesium ion has been converted to a charge of +2 to +1
During DNA replication, one of the new strands of DNA is synthesized continuously, while the other is synthesized as a number of separate fragments of DNA that are subsequently linked by DNA ligase. This is because O replication starts at many points on the chromosome RNA primers only anneal to one of the parental strands of DNA one of the parental strands is unwound slower than the other by helicase DNA polymerase III only synthesizes DNA in the 5' - 3' direction
DNA synthesis by DNA polymerases exemplitiės Q6 DNA synthesis Growing strand Template (primer) strand DNA polymerase G NH DNA primer Mg2+ NH2 Asp- Asp- 5' P-0 3' OH OH Mg2+ Incoming DNTP H. Incoming DNTP 0-P=0 Mg H. Mg CH H. Can you' rationalize or explain why dNTP (deoxyribonucleotide triphosphate) instead of DNMP (deoxyribonucleotide monophosphate) has been selected by evolution as the reactant and a DNA polymerase is also required to catalyze the reaction (to a reasonable rate of ~1000-events per second) in living systems? Hint: Ea of the reaction without catalysis is about 30 kcal/mol.
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vvnicn the following statements are correct about the repair of a DNA duplex containing the sequence below that is grown INE coli (select all that apply)? Strand A Strand B GATCTAGCCGGCATCCGAT CTAGATCGGACGTAGGCTA Methyl ✔A. MutH cleaves Strand A O B. DNA repair will result in the bold A in strand B being replaced with a C O C. DNA repair will result in the bold G in strand A being replaced with a T ✔ D. Defect will not be properly repaired in dam(-) E coli O E. The mammalian repair system would also correct the mismatch shown based on the methylation status of the DNA
Ultraviolet light can cause covalent linkages between consecutive pyrimidine bases in DNA (up to 100 per second in a single cell in sunlight!). These bulky lesions (i.e. cyclobutane pyrimidine dimers and 6-4 photoproducts), which inhibit DNA and RNA polymerases, are mostly reversed by CPD photolyase when light >300 nm is available to power the reaction. In the dark, however, which DNA repair system is best able to correct these errors? a) non-homologous end-joining b) mismatch repairc) nucleotide-excision repaird) base-excision repair e) homology-directed repair
Which of the following statement(s) correctly describe(s) telomerase? Select all that apply. You may select multiple options. ✔Telomerase synthesizes DNA from an RNA template. O All of these options O Telomerase extends the lengths of telomeres of linear chromosomes in eukaryotes. O Telomerase unwinds the DNA duplex at telomeres. Telomerase serves as a primer for DNA synthesis at telomeres. O Telomerase has 5'-to-3' exonuclease activity.
Step 1 Lys Lys Ligase-AMP NH2 NH2 NH2 `NH2 PP АТР он он OH Step 2 Lys Lys NH2 NH2 NH2 NH2 DNA- OH OH Adenylate OH OH HO. Step 3 NH2 NH2 NH2 NH2 AMP Phospho- diester OH OH OH OH OH Describe the mechanism shown above for DNA Ligase. Describe the chemistry of each step How the enzyme appears or might facilitate the chemistry How the enzyme increases the reaction rate.
Given the active site diagram below, please identify the residue participating in a charge-charge interation. HO OH HN OH 5 ΝΗ *HN ΝΗ OH O Zn²+ 2 4 5 3 1 2 NH 3
During DNA replication, the function of RNA primers is to serve as a binding site for DNA ligase open replication bubbles O serve as starting points for DNA strand elongation by DNA polymerase I in the 3' - 5' direction as starting points for DNA strand elongation by DNA polymerase III in ser prokaryotes prevent new-separated strands of DNA from rejoining
Proof-reading during DNA replication refers to: * O removal of thymine dimers by by excision repair O none of the above checking for correct base pairing by DNA polymerase removal of the RNA primer before connecting Okazaki fragments O pairing of A with T and G with C by DNA polymerase