d. a homozygous mutation that completely eliminates the coding region of a tumor suppressor gene e. a heterozygote where one allele is the mutant allele described in (c), the other allele being wild type f. a heterozygote where one allele is the mutant allele described in (d), the other allele being wild type

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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D,E,F

1. Explain BRIEFLY whether each of the following conditions will increase or decrease the
chance of cancer:
a. a mutation in the promoter region of a tumor suppressor gene that results in that gene
being overexpressed (assume that the cell is heterozygous for the mutation)
Decrease, the more the expression of tumor-suppressing genes the better the regulation of the
cell cycle, and less chance of uncontrolled cell division.
b. a mutation in the promoter region of a protooncogene that results in that gene being
overexpressed (assume that the cell is heterozygous for the mutation)
increase, the more the expression of protooncogenes the more will be the chances of tumor
formation.
c. a homozygous mutation that completely eliminates the coding region of a protooncogene
decrease, the protoncogene becomes non-functional due to the elimination of its coding region
and it would not be able to promote tumor formation
d. a homozygous mutation that completely eliminates the coding region of a tumor
suppressor gene
e. a heterozygote where one allele is the mutant allele described in (c), the other allele
being wild type
f.
a heterozygote where one allele is the mutant allele described in (d), the other allele
being wild type
Transcribed Image Text:1. Explain BRIEFLY whether each of the following conditions will increase or decrease the chance of cancer: a. a mutation in the promoter region of a tumor suppressor gene that results in that gene being overexpressed (assume that the cell is heterozygous for the mutation) Decrease, the more the expression of tumor-suppressing genes the better the regulation of the cell cycle, and less chance of uncontrolled cell division. b. a mutation in the promoter region of a protooncogene that results in that gene being overexpressed (assume that the cell is heterozygous for the mutation) increase, the more the expression of protooncogenes the more will be the chances of tumor formation. c. a homozygous mutation that completely eliminates the coding region of a protooncogene decrease, the protoncogene becomes non-functional due to the elimination of its coding region and it would not be able to promote tumor formation d. a homozygous mutation that completely eliminates the coding region of a tumor suppressor gene e. a heterozygote where one allele is the mutant allele described in (c), the other allele being wild type f. a heterozygote where one allele is the mutant allele described in (d), the other allele being wild type
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