Please explain parts D and E only. Reposting for continued responses. This is Biochem. Please explain each part thoroughly. 1. The following reactions can be coupled in the citrate cycle.kJ/molkJ/molSuccinyl-CoAGDP + Pi.succinate+CoAGTPGº=-34.0Gº= 30.5a) Write the net reaction. Calculate Gº for the coupled reaction. Is the reaction favorable?b) Write the equilibrium constant in terms of reactant and product concentration. Calculate the equilibrium constant,K, for the coupled reaction at 37°C.c) If the ratio of [GTP/[GDP] in the cell is 22, the [CoA]/[succinyl-CoA] ratio is 0.20, and the [Pi] is 1.3mM,determine the [Succinate] at equilibrium. (Pay attention to concentration units)d) If the [GTP/[GDP] falls to 2.0, calculate G, keeping all other concentrations the same including succinate fromabove. If the [GTP/[GDP] increases to 100, calculate []G, keeping all other concentrations the same.e) What conclusion can you reach about the direction of the reaction under these cellular conditions? Is this reactionreversible or irreversible?

The Krebs cycle which is also known as the TCA cycle (tricarboxylic acid cycle) or Citric acid…

d) If the [GTP/[GDP] falls to 2.0, calculate G, keeping all other concentrations the same including succinate from above. If the [GTP/[GDP] increases to 100, calculate G, keeping all other concentrations the same. e) What conclusion can you reach about the direction of the reaction under these cellular conditions? Is this reaction reversible or irreversible?

d) If the [GTP/[GDP] falls to 2.0, calculate G, keeping all other concentrations the same including succinate from above. If the [GTP/[GDP] increases to 100, calculate G, keeping all other concentrations the same. e) What conclusion can you reach about the direction of the reaction under these cellular conditions? Is this reaction reversible or irreversible?

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Question

Please explain parts D and E only. Reposting for continued responses. This is Biochem. Please explain each part thoroughly.

1. The following reactions can be coupled in the citrate cycle.
kJ/mol
kJ/mol
Succinyl-CoA
GDP + Pi.
succinate+CoA
GTP
Gº=-34.0
Gº= 30.5
a) Write the net reaction. Calculate Gº for the coupled reaction. Is the reaction favorable?
b) Write the equilibrium constant in terms of reactant and product concentration. Calculate the equilibrium constant,
K, for the coupled reaction at 37°C.
c) If the ratio of [GTP/[GDP] in the cell is 22, the [CoA]/[succinyl-CoA] ratio is 0.20, and the [Pi] is 1.3mM,
determine the [Succinate] at equilibrium. (Pay attention to concentration units)
d) If the [GTP/[GDP] falls to 2.0, calculate G, keeping all other concentrations the same including succinate from
above. If the [GTP/[GDP] increases to 100, calculate []G, keeping all other concentrations the same.
e) What conclusion can you reach about the direction of the reaction under these cellular conditions? Is this reaction
reversible or irreversible?

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Step 1: Citrate cycle

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