CO0 CO0- CH, CH, CH, HC- NH,+ CO0- CO0- Asp Succinate [Asp] [Succinate] [Asp] In experiment b (a) (b)
Nucleotides
It is an organic molecule made up of three basic components- a nitrogenous base, phosphate,and pentose sugar. The nucleotides are important for metabolic reactions andthe formation of DNA (deoxyribonucleic acid) and RNA (ribonucleic acid).
Nucleic Acids
Nucleic acids are essential biomolecules present in prokaryotic and eukaryotic cells and viruses. They carry the genetic information for the synthesis of proteins and cellular replication. The nucleic acids are of two types: deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). The structure of all proteins and ultimately every biomolecule and cellular component is a product of information encoded in the sequence of nucleic acids. Parts of a DNA molecule containing the information needed to synthesize a protein or an RNA are genes. Nucleic acids can store and transmit genetic information from one generation to the next, fundamental to any life form.
The allosterically regulated enzyme ATCase binds aspartic acid as a substrate and acylates the α–amino group. Succinate acts as a competitive
inhibitor of ATCase because it binds the active site but can’t be acylated.
The dependence of v0 on [aspartic acid] for ATCase is shown in panel (a)
of the accompanying figure. Panel (b) shows the effect of increasing [succinate] on v0 when [Asp] is held at a low concentration (see thick vertical arrow in panel (a)). Note that in panel (b), v0 is not zero when [succinate] = 0 (see thin horizontal arrow). Explain the shape of the curve in panel (b). Why does v0 increase initially, before decreasing at higher [succinate]?
![CO0
CO0-
CH,
CH,
CH,
HC- NH,+
CO0-
CO0-
Asp
Succinate
[Asp]
[Succinate]
[Asp] In
experiment b
(a)
(b)](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Ff9f03da3-4e26-4892-899c-52e584df7b6d%2F639ba2c1-fcb4-4283-8254-ec26cfb9124a%2Fa2ba47_processed.png&w=3840&q=75)
Step by step
Solved in 3 steps with 1 images
