Consider the tripeptide Thr-Arg-Tyr.  1. Name: T-R-Y_______________________ 2. Draw the structure of the fully protonated form of the tripeptide and label the ionizable groups with the corresponding pKa values.  3. Draw predominant structure of the tripeptide at pH 11. What is the net charge?    Consider the image as an example. Thank you.

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Consider the tripeptide Thr-Arg-Tyr. 

1. Name: T-R-Y_______________________

2. Draw the structure of the fully protonated form of the tripeptide and label the ionizable groups with the corresponding pKa values. 

3. Draw predominant structure of the tripeptide at pH 11. What is the net charge? 

 

Consider the image as an example. Thank you.

 

 

 

Example: Glu-Cys-Gly – ECG, glutamylcysteinylglycine
HOH HOHHO
| II 1 1 || | | ||
9.67 H3N-C-C-N-C-C-N-C-C-OH 2.34
|
CH₂
CH₂
CH₂
C=0
OH
4.25
SH
8.18
1
H
fully protonated form
O=O
Н H O Н
|||
c-c
1
CH₂
H
||
H₂N-C-C-N-
-8-8-8
HIZ
____
HIZ
HIC-H
010
O
с C
at pH 11
net charge: -3
Transcribed Image Text:Example: Glu-Cys-Gly – ECG, glutamylcysteinylglycine HOH HOHHO | II 1 1 || | | || 9.67 H3N-C-C-N-C-C-N-C-C-OH 2.34 | CH₂ CH₂ CH₂ C=0 OH 4.25 SH 8.18 1 H fully protonated form O=O Н H O Н ||| c-c 1 CH₂ H || H₂N-C-C-N- -8-8-8 HIZ ____ HIZ HIC-H 010 O с C at pH 11 net charge: -3
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