Consider the structure of the alkyl halide shown. H3C CH3 Br Compounds A through F are possible substitution or elimination products. A CH3 H3C. O Fox -CH3 H3C CH3 H₂C. B E CH3 0 CH3 H₂C H3C CH3 -CH3 8 3 H3C F C H3C -CH3 -CH3
Reactions of Ethers
Ethers (R-O-R’) are compounds formed by replacing hydrogen atoms of an alcohol (R-OH compound) or a phenol (C6H5OH) by an aryl/ acyl group (functional group after removing single hydrogen from an aromatic ring). In this section, reaction, preparation and behavior of ethers are discussed in the context of organic chemistry.
Epoxides
Epoxides are a special class of cyclic ethers which are an important functional group in organic chemistry and generate reactive centers due to their unusual high reactivity. Due to their high reactivity, epoxides are considered to be toxic and mutagenic.
Williamson Ether Synthesis
An organic reaction in which an organohalide and a deprotonated alcohol forms ether is known as Williamson ether synthesis. Alexander Williamson developed the Williamson ether synthesis in 1850. The formation of ether in this synthesis is an SN2 reaction.
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O Macmillan Learning
Consider the structure of the alkyl halide shown.
H3C
CH3
Br
Compounds A through F are possible substitution or elimination products.
C
A
H3C
CH3
H3C.
-CH3
* J
-CH3
H3C CH3
H3C CH3
ợ
D
H3C.
H₂C
B
E
CH3
H3C
-CH3
đờ
CH3
-CH3"
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>
CH3
H3C
H3C.
-CH3
18 Bez z
-CH3
H3C CH3
O Macmillan Learning
H3C
CH 3
Ő
D
H3C
H₂C
E
CH3
CH3
-CH3
Identify the product when the alkyl bromide is treated
with sodium methoxide in DMSO.
E
C
F
B
A
D
H3C
o
F
-CH3
Identify the product when the alkyl bromide is treated
with sodium t-butoxide in DMSO.
D
F
C
A
B
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