Consider the retrosynthesis of the following target molecule. Provide at least two possible starting materials that could be used to prepare the target molecule. Br Select the compounds (plus reagents) that would be suitable starting materials for an efficient synthesis of the given target molecule. Select all that apply.

A4 Express the retro synthesis scheme using the suggested starting material (SM) for the following target compound (TM). After performing the retro synthesis analysis, synthesize the target compound according to the analyzed scheme.

Aldol Condensation- Synthesis of Dibenzalacetone The protocol says that, after adding in all the reactants, stir for an additional 15 minutes.  A student swirled for only 8 minutes and then, correctly, stopped and proceeded with isolating the product.  What did the student do that gave such confidence and accuracy?

Consider the synthetic sequence shown. Identify the reagents for all three steps. Draw the structures of organic compounds A and B. Omit byproducts. Reagents: 1) 03, 2) Zn, H₂O Mg 1) ethylene oxide 2) H₂O+ 1) 03, 2) H₂O₂ 1) CH₂CO3H 2) H₂O PCC H₂, Pt 1) CH₂MgBr 2) H3O+ reagent 1 compound A Br reagent 2 compound B reagent 3 H

CORRECT OR INCORRECT    Alkylating agents react with DNA and form covalent bonds.   Ciprofloxacin is a member of a group of compounds called fluoroquinolones which act by stabilizing a complex between the topoisomerase enzyme and DNA.   Chain cutting agents usually bind to DNA and generate radical species which result in the cutting of the DNA chain.   Intercalating agents are agents that can bind to DNA and insert planar regions of their skeleton between the base pairs of DNA.   Agents which inhibit the polymerization or depolymerization of microtubules are important anticancer agents.   Paclitaxel and its derivatives bind to tubulin and accelerate depolymerization by stabilizing the resulting microtubules.   Drugs that target viral structural proteins can prevent viruses from entering host cells by inhibiting the uncoating process.   Etoposide and Teniposide are non-intercalating drugs that act as Topoisomerase 1 poisons.…

Reaction Quenching. Our cinnamaldehyde to cinnamyl alcohol reduction reaction is being quenched using HCl. Why do we use this reagent? Explain, in words and by drawing out acid/base chemistry reactions, what the quench would accomplish. Be sure to use pKa values in your explanation. HINT: there are 3 different quench reactions that occur. Look at the reagents and the mechanism for what species exist in the reaction mixture that can react with HCl. Cinnamaldehyde MW: 132.16 g/mol b.p. 248°C NaBH4, CH₂CH₂OH Diethyl Ether, 0°C OH Cinnamyl alcohol MW: 134.18 g/mol m.p. 30-33°C

Put the reagents and intermediates in correct order to complete the following synthesis.

Perform the retrosynthesis (with its structure) and the synthetic route of the molecule below OH

If you answered "yes" for the first susbtrate, draw the intermediate that forms during a nucleophilic substitution reaction in the space below the table.

Which of these puzzle pieces will fit for the synthesis?