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Consider the oxidation of a mole of NADH using the following half reactions: 12 02+2 e + 2 H+ → H₂O NAD+ + 2 e + H* → NADH E" = 0.83 V E = -0.32 V a) Determine E" and AG" for the oxidation of a mole of NADH by oxygen. Show all work for the calculation of both values and write out the overall reaction. b) Assume that this occurred in a mitochondria with a defective complex IV that resulted in no proton pumping at complex IV (all other complexes pumped protons in their normal fashion). How many moles of protons are pumped as a result of the oxidation of a mole of NADH using this slightly defective electron transport chain? c) If all of the protons calculated above could be used for ATP production by the mitochondrial ATP synthase, how many moles of ATP could be produced? d) If the AG for ATP synthesis is about 50 kJ/mol, what percentage of the energy from NADH oxidation is captured in ATP formation?

Consider the oxidation of a mole of NADH using the following half reactions: 12 02+2 e + 2 H+ → H₂O NAD+ + 2 e + H* → NADH E" = 0.83 V E = -0.32 V a) Determine E" and AG" for the oxidation of a mole of NADH by oxygen. Show all work for the calculation of both values and write out the overall reaction. b) Assume that this occurred in a mitochondria with a defective complex IV that resulted in no proton pumping at complex IV (all other complexes pumped protons in their normal fashion). How many moles of protons are pumped as a result of the oxidation of a mole of NADH using this slightly defective electron transport chain? c) If all of the protons calculated above could be used for ATP production by the mitochondrial ATP synthase, how many moles of ATP could be produced? d) If the AG for ATP synthesis is about 50 kJ/mol, what percentage of the energy from NADH oxidation is captured in ATP formation?

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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5. Consider the oxidation of a mole of NADH using the following half reactions: 12 O2 + 2 e + 2 H+ → H₂O NAD + 2 e + H+ → NADH E = 0.83 V E" = -0.32 V a) Determine E" and AG" for the oxidation of a mole of NADH by oxygen. Show all work for the calculation of both values and write out the overall reaction. b) Assume that this occurred in a mitochondria with a defective complex IV that resulted in no proton pumping at complex IV (all other complexes pumped protons in their normal fashion). How many moles of protons are pumped as a result of the oxidation of a mole of NADH using this slightly defective electron transport chain? c) If all of the protons calculated above could be used for ATP production by the mitochondrial ATP synthase, how many moles of ATP could be produced? d) If the AG for ATP synthesis is about 50 kJ/mol, what percentage of the energy from NADH oxidation is captured in ATP formation?
Transcribed Image Text:5. Consider the oxidation of a mole of NADH using the following half reactions: 12 O2 + 2 e + 2 H+ → H₂O NAD + 2 e + H+ → NADH E = 0.83 V E" = -0.32 V a) Determine E" and AG" for the oxidation of a mole of NADH by oxygen. Show all work for the calculation of both values and write out the overall reaction. b) Assume that this occurred in a mitochondria with a defective complex IV that resulted in no proton pumping at complex IV (all other complexes pumped protons in their normal fashion). How many moles of protons are pumped as a result of the oxidation of a mole of NADH using this slightly defective electron transport chain? c) If all of the protons calculated above could be used for ATP production by the mitochondrial ATP synthase, how many moles of ATP could be produced? d) If the AG for ATP synthesis is about 50 kJ/mol, what percentage of the energy from NADH oxidation is captured in ATP formation?
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