Consider the following sequence of DNA: 3' - TACATGIIGTAG-5' a) Create a nonsense mutation with the DNA strand and show the effects of the mutation on the amino acid sequence. Clearly indicate where the mutation is and state any consequences of the mutation. b) Provide any two examples of chromosomal mutations. Briefly explain each example. MRNA Codon/Amino Acid Chart First Base Second Base Third Base U A G UGU1 Fysteine (Cys) UGCJ UUU Phenylalanine UCU UAUJ Tyrosine (Tyr) UACJ UUCJ (Phe) UCC Serine (Ser) UCA U UUA FLeucine (Leu) UUG UGA - Stop A UAAT FStop UCG UAG. UGG- Tryptophan (Trp) CAU Histidine (His) CAC CUUT CU CGU CGC CUC FLeucine (Leu) CUA Proline (Pro) CCA Arginine (Arg) CGA CAA1 Glutamine A CUG- CCG CAGJ (Glu) CGG- ACU AAUJ Asparagine AGUT FSerine (Ser) AGC- AUUT AUC Fisoleucine (lle) ACC Threonine AACJ (Asn) A AUAJ (Thr) AAA FLysine (Lys) AGA Arginine (Arg) AGG! AÇA A Start Methionine AUG-Met) ACG- AAG- G GCU- GAUJ Aspartic Acid GUUT GGUT GAC (Asp) GGC GUC Valine (Val) GUA GCC Alanine (Ala) GCA G Glycine (Gly) GAAJ Glutamic Acid GGA GUG- GCG- GAGJ (Glu) GGG- G

Human Anatomy & Physiology (11th Edition)
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Author:Elaine N. Marieb, Katja N. Hoehn
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Chapter1: The Human Body: An Orientation
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Consider the following sequence of DNA:
3' - TACATGTTGTAG-5'
a) Create a nonsense mutation with the DNA strand and show the effects of the
mutation on the amino acid sequence. Clearly indicate where the mutation is and
state any consequences of the mutation.
b) Provide any two examples of chromosomal mutations. Briefly explain each
example.
MRNA Codon/Amino Acid Chart
First Base
Second Base
Third Base
A
000L Phenylalanine UCU
UUCJ (Phe)
UAU1
Tyrosine (Tyr)
UACJ
UGUT
UGCysteine (Cys)
UCC
Serine (Ser)
UCA
UUA,
FLeucine (Leu)
UUGJ
UGA - Stop
A
UAA1
Fstop
UAGJ
UCG-
UGG - Tryptophan (Trp)
CAU1
FHistidine (His)
CAC
CUUT
CCU1
CGU1
CUC
FLeucine (Leu)
CỦA
CC
Proline (Pro)
CCA
CGC
FArginine (Arg)
CGA
CAA1 Glutamine
A
CUG-
CCG-
CAGJ (Glu)
CGG-
AUU
AAU1 Asparagine
AAC (Asn)
ACUT
AGUT
U
Serine (Ser)
AGC-
AUC FIsoleucine (le) ACC Threonine
A
AUAJ
АСА
(Thr)
AAA1
FLysine (Lys)
AAG-
AGA,
FArginine (Arg)
AGG-
A
Start Methionine
AUG -
(Met)
ACG-
G
GAUJ Aspartic Acid
GAC(Asp)
GUU-
GCU
GGU
U
GUC
Fvaline (Val)
GUA
GCC
FAlanine (Ala)
GGC
G
Glycine (Gly)
GCA
GAA1 Glutamic Acid GGA
A
GUG-
GCG-
GAGJ (Glu)
GGG-
G
Transcribed Image Text:Consider the following sequence of DNA: 3' - TACATGTTGTAG-5' a) Create a nonsense mutation with the DNA strand and show the effects of the mutation on the amino acid sequence. Clearly indicate where the mutation is and state any consequences of the mutation. b) Provide any two examples of chromosomal mutations. Briefly explain each example. MRNA Codon/Amino Acid Chart First Base Second Base Third Base A 000L Phenylalanine UCU UUCJ (Phe) UAU1 Tyrosine (Tyr) UACJ UGUT UGCysteine (Cys) UCC Serine (Ser) UCA UUA, FLeucine (Leu) UUGJ UGA - Stop A UAA1 Fstop UAGJ UCG- UGG - Tryptophan (Trp) CAU1 FHistidine (His) CAC CUUT CCU1 CGU1 CUC FLeucine (Leu) CỦA CC Proline (Pro) CCA CGC FArginine (Arg) CGA CAA1 Glutamine A CUG- CCG- CAGJ (Glu) CGG- AUU AAU1 Asparagine AAC (Asn) ACUT AGUT U Serine (Ser) AGC- AUC FIsoleucine (le) ACC Threonine A AUAJ АСА (Thr) AAA1 FLysine (Lys) AAG- AGA, FArginine (Arg) AGG- A Start Methionine AUG - (Met) ACG- G GAUJ Aspartic Acid GAC(Asp) GUU- GCU GGU U GUC Fvaline (Val) GUA GCC FAlanine (Ala) GGC G Glycine (Gly) GCA GAA1 Glutamic Acid GGA A GUG- GCG- GAGJ (Glu) GGG- G
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