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Consider a uniport system where a carrier protein transports an uncharged substance A across a cell membrane. Suppose that at a certain ratio of [A]inside to [A]outside, the AG for the transport of substance A from outside the cell to the inside, Aoutside → Ainside, is -12.1 kJ/mol at 25°C. What is the ratio of the concentration of substance A inside the cell to the concentration outside? [A]inside [A]outside 321.1 Incorrect Choose the true statement about the transport of A under the conditions described. Because AG is negative, the ratio [A]inside/[A]outside must be greater than one. Increasing [A]outside will cause AG for movement of Aoutside to Ainside to become a smaller negative number. Decreasing the concentration of the uniport protein in the membrane will cause AG to become a larger negative number. Movement of Aoutside to Ainside will be spontaneous.

Consider a uniport system where a carrier protein transports an uncharged substance A across a cell membrane. Suppose that at a certain ratio of [A]inside to [A]outside, the AG for the transport of substance A from outside the cell to the inside, Aoutside → Ainside, is -12.1 kJ/mol at 25°C. What is the ratio of the concentration of substance A inside the cell to the concentration outside? [A]inside [A]outside 321.1 Incorrect Choose the true statement about the transport of A under the conditions described. Because AG is negative, the ratio [A]inside/[A]outside must be greater than one. Increasing [A]outside will cause AG for movement of Aoutside to Ainside to become a smaller negative number. Decreasing the concentration of the uniport protein in the membrane will cause AG to become a larger negative number. Movement of Aoutside to Ainside will be spontaneous.

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Q13 // CH 12

Consider a uniport system where a carrier protein transports an uncharged substance A across a cell membrane. Suppose that at a certain ratio of [A]inside to [A]outside, the AG for the transport of substance A from outside the cell to the inside, Aoutside → Ainside, is -12.1 kJ/mol at 25°C. What is the ratio of the concentration of substance A inside the cell to the concentration outside? [A]inside [A]outside 321.1 Incorrect Choose the true statement about the transport of A under the conditions described. Because AG is negative, the ratio [A]inside/[A]outside must be greater than one. Increasing [A]outside will cause AG for movement of Aoutside to Ainside to become a smaller negative number. Decreasing the concentration of the uniport protein in the membrane will cause AG to become a larger negative number. Movement of Aoutside to Ainside will be spontaneous.
Transcribed Image Text:Consider a uniport system where a carrier protein transports an uncharged substance A across a cell membrane. Suppose that at a certain ratio of [A]inside to [A]outside, the AG for the transport of substance A from outside the cell to the inside, Aoutside → Ainside, is -12.1 kJ/mol at 25°C. What is the ratio of the concentration of substance A inside the cell to the concentration outside? [A]inside [A]outside 321.1 Incorrect Choose the true statement about the transport of A under the conditions described. Because AG is negative, the ratio [A]inside/[A]outside must be greater than one. Increasing [A]outside will cause AG for movement of Aoutside to Ainside to become a smaller negative number. Decreasing the concentration of the uniport protein in the membrane will cause AG to become a larger negative number. Movement of Aoutside to Ainside will be spontaneous.
Expert Solution
Step 1: Free energy change for transport of uncharged solute

The following equation describes the mathematical relation for the change in free energy (increment G) required to transport a solute across a biological membrane: 

increment G space equals space R times T times ln fraction numerator C 2 over denominator C 1 end fraction

where:

  • R is the gas constant 8.314 J mol-1 K-1
  • T is the temperature in Kelvin
  • C2 is the ion concentration of where the ion is going to
  • C1 is the ion concentration of where the ion is coming from 
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