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Complete the table below to describe the phenotypic consequences for a loss-of-function allele and separately for a gain-of-function allele in each of the genes listed. This is in a somatic cells, in a diploid organism. Consequences should be at the cellular level. The table below considers two genes and asks you to predict consequences if a cell is heterozygous and homozygous for the indicated allele, for both loss of function (LOF) and gain of function (GOF) alleles. You should also indicate if the genotypes could be inherited and if so, would it be a lethal genotype? Lastly, label each gene as either a proto-oncogene or a tumor suppressor gene.

Complete the table below to describe the phenotypic consequences for a loss-of-function allele and separately for a gain-of-function allele in each of the genes listed. This is in a somatic cells, in a diploid organism. Consequences should be at the cellular level. The table below considers two genes and asks you to predict consequences if a cell is heterozygous and homozygous for the indicated allele, for both loss of function (LOF) and gain of function (GOF) alleles. You should also indicate if the genotypes could be inherited and if so, would it be a lethal genotype? Lastly, label each gene as either a proto-oncogene or a tumor suppressor gene.

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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1. Complete the table below to describe the phenotypic consequences for a loss-of-function allele and separately for a gain-of-function allele in each of the genes listed. This is in a somatic cells, in a diploid organism. Consequences should be at the cellular level. The table below considers two genes and asks you to predict consequences if a cell is heterozygous and homozygous for the indicated allele, for both loss of function (LOF) and gain of function (GOF) alleles. You should also indicate if the genotypes could be inherited and if so, would it be a lethal genotype? Lastly, label each gene as either a proto-oncogene or a tumor suppressor gene. Be sure to state any assumptions you are making. See sample answer in first box. Type of allele Normal Gene Genotype (+ product (e.g. Loss of Function Gain of Function is wildtype, - is mutant) protein) function Phenotype: E.g., no Phenotype: МҮС, а transcription factor that phenotypic change at cellular or organismal levels (assuming + allele is haplosufficient). stimulates Heterozygote Could inherit the LOF allele progression (+/-) b/c it shouldn't be lethal from G1 to S during development (based phase (proto- oncogene). on wild-type haplosufficiency assumption)
Transcribed Image Text:1. Complete the table below to describe the phenotypic consequences for a loss-of-function allele and separately for a gain-of-function allele in each of the genes listed. This is in a somatic cells, in a diploid organism. Consequences should be at the cellular level. The table below considers two genes and asks you to predict consequences if a cell is heterozygous and homozygous for the indicated allele, for both loss of function (LOF) and gain of function (GOF) alleles. You should also indicate if the genotypes could be inherited and if so, would it be a lethal genotype? Lastly, label each gene as either a proto-oncogene or a tumor suppressor gene. Be sure to state any assumptions you are making. See sample answer in first box. Type of allele Normal Gene Genotype (+ product (e.g. Loss of Function Gain of Function is wildtype, - is mutant) protein) function Phenotype: E.g., no Phenotype: МҮС, а transcription factor that phenotypic change at cellular or organismal levels (assuming + allele is haplosufficient). stimulates Heterozygote Could inherit the LOF allele progression (+/-) b/c it shouldn't be lethal from G1 to S during development (based phase (proto- oncogene). on wild-type haplosufficiency assumption)
Homozygote (-1-) Heterozygote (+/-) VHL. Normally suppresses cell division (tumor- suppressor gene). Homozygote (-/-)
Transcribed Image Text:Homozygote (-1-) Heterozygote (+/-) VHL. Normally suppresses cell division (tumor- suppressor gene). Homozygote (-/-)
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