Codon in DNA Codon in mRNA Amino acid template strand APP gene in individuals without САА GUU Valine (Val) Alzheimer's disease APP gene in individuals with CỦA GAU Aspartate (Asp) Alzheimer's disease Does this change in codon represent a silent or a missense mutation? Explain
Codon in DNA Codon in mRNA Amino acid template strand APP gene in individuals without САА GUU Valine (Val) Alzheimer's disease APP gene in individuals with CỦA GAU Aspartate (Asp) Alzheimer's disease Does this change in codon represent a silent or a missense mutation? Explain
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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Transcribed Image Text:4. Compare the DNA sequences of individuals with Alzheimer's disease and their family
members. Two codons in the APP gene sequence are different in the two patients with
Alzheimer's disease compared to individuals without the disease. Consider the first codon
that's different and complete the table below.
Codon in
Codon in
Amino Acid
DNA template strand
MRNA
APP gene in individuals
3'-CAA-5'
5'-GUU-3'
valine
without Alzheimer's
disease
leucine
APP gene in individuals
3'-GAA-5'
5'-CUU-3'
with Alzheimer's disease
Does the change in this codon represent a silent or a missense mutation? Explain.
This would bring about a missense mutation that changes the amino acid from
valine to leucine. It's referred to as missense mutation because in the mutation
there is one amino acid it is then changed into another amino acid.
Codon in DNA
Codon in mRNA
Amino acid
template strand
APP gene in
individuals without
САА
GUU
Valine (Val)
Alzheimer's disease
APP gene in
individuals with
CUA
GAU
Aspartate (Asp)
Alzheimer's disease
Does this change in codon represent a silent or a missense mutation? Explain
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