Ciprofloxacin has a carboxylic acid group of pKa 6.09 and a secondary amine group of pKa 8.74. Using the Henderson-Hasselbalch equation, determine determine which functional groups of the molecule will be ionized in the stomach (pH 1) and in the colon (pH 6). Show your calcultions. It is not necessary to calculate the degree of ionization. HN, pka 8.74 Ciprofloxcin COOH pka 6.09
Ciprofloxacin has a carboxylic acid group of pKa 6.09 and a secondary amine group of pKa 8.74. Using the Henderson-Hasselbalch equation, determine determine which functional groups of the molecule will be ionized in the stomach (pH 1) and in the colon (pH 6). Show your calcultions. It is not necessary to calculate the degree of ionization. HN, pka 8.74 Ciprofloxcin COOH pka 6.09
Principles of Modern Chemistry
8th Edition
ISBN:9781305079113
Author:David W. Oxtoby, H. Pat Gillis, Laurie J. Butler
Publisher:David W. Oxtoby, H. Pat Gillis, Laurie J. Butler
Chapter15: Acid–base Equilibria
Section: Chapter Questions
Problem 79AP
Related questions
Question
Expert Solution
Step 1
Due to the acidic nature of carboxylic acids, their level of dissociation is directly related to the pH of the solution. Under acidic conditions (low pH), carboxylic acids are almost completely undissociated and exist primarily in their protonated form (RCOOH). Under, basic conditions (high pH), carboxylic acids become nearly completely dissociated into their deprotonated carboxylate form (RCOO−). Because the environment inside a living cell is an aqueous buffer with a nearly neutral pH = 7.3 (sometimes referred to as the physiological pH
Trending now
This is a popular solution!
Step by step
Solved in 2 steps
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, chemistry and related others by exploring similar questions and additional content below.Recommended textbooks for you
Principles of Modern Chemistry
Chemistry
ISBN:
9781305079113
Author:
David W. Oxtoby, H. Pat Gillis, Laurie J. Butler
Publisher:
Cengage Learning
Chemistry
Chemistry
ISBN:
9781305957404
Author:
Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:
Cengage Learning
Chemistry: An Atoms First Approach
Chemistry
ISBN:
9781305079243
Author:
Steven S. Zumdahl, Susan A. Zumdahl
Publisher:
Cengage Learning
Principles of Modern Chemistry
Chemistry
ISBN:
9781305079113
Author:
David W. Oxtoby, H. Pat Gillis, Laurie J. Butler
Publisher:
Cengage Learning
Chemistry
Chemistry
ISBN:
9781305957404
Author:
Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:
Cengage Learning
Chemistry: An Atoms First Approach
Chemistry
ISBN:
9781305079243
Author:
Steven S. Zumdahl, Susan A. Zumdahl
Publisher:
Cengage Learning