QUESTION 11Ciprofloxacin has a carboxylic acid group of pKa 6.09 and a secondary amine group of pKa 8.74. Using the Henderson-Hasselbalch equation, determine determine which functional groups of the molecule will beionized in the stomach (pH 1) and in the colon (pH 6). Show your calcultions. It is not necessary to calculate the degree of ionization.HNpka 8.74F`NCiprofloxcin`NCOOHpka 6.09

Answered: Ciprofloxacin has a carboxylic acid…

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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Due to the acidic nature of carboxylic acids, their level of dissociation is directly related to the pH of the solution. Under acidic conditions (low pH), carboxylic acids are almost completely undissociated and exist primarily in their protonated form ( $RCOOH$ ). Under, basic conditions (high pH), carboxylic acids become nearly completely dissociated into their deprotonated carboxylate form ( ${RCOO}^{-}$ ). Because the environment inside a living cell is an aqueous buffer with a nearly neutral pH = 7.3 (sometimes referred to as the physiological pH

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