# Ranking the Reactivity of Molecules as Electrophiles ### Instructions: 1. Rank the following molecules from most to least reactive as electrophiles (1 = most reactive). 2. Be sure to explain your rankings considering both steric and electronic effects. ### Molecules: - **A:** Structure with a ketone group (CH3C=OCH3) - **B:** Structure with an ester group (CH3C=OCH(CH3)2) - **C:** Structure with a trifluoromethyl group (F3CC=OH) - **D:** Formaldehyde structure (H2C=O) ### Table for Ranking and Reasoning: | Molecule | Rank | Reasoning | |----------|------|-----------| | A | | | | B | | | | C | | | | D | | | ### Explanation Guidelines: - **Steric Effects:** Consider the size and shape of the molecules. Bulky groups can hinder reactivity. - **Electronic Effects:** Consider the presence of electron-withdrawing or electron-donating groups. Electron-withdrawing groups typically increase electrophilicity. Please fill in the ranks and reasoning based on your analysis of steric and electronic effects.

# Ranking the Reactivity of Molecules as Electrophiles ### Instructions: 1. Rank the following molecules from most to least reactive as electrophiles (1 = most reactive). 2. Be sure to explain your rankings considering both steric and electronic effects. ### Molecules: - A: Structure with a ketone group (CH3C=OCH3) - B: Structure with an ester group (CH3C=OCH(CH3)2) - C: Structure with a trifluoromethyl group (F3CC=OH) - D: Formaldehyde structure (H2C=O) ### Table for Ranking and Reasoning: | Molecule | Rank | Reasoning | |----------|------|-----------| | A | | | | B | | | | C | | | | D | | | ### Explanation Guidelines: - Steric Effects: Consider the size and shape of the molecules. Bulky groups can hinder reactivity. - Electronic Effects: Consider the presence of electron-withdrawing or electron-donating groups. Electron-withdrawing groups typically increase electrophilicity. Please fill in the ranks and reasoning based on your analysis of steric and electronic effects.

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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1) The first mechanistic step of an acid catalyzed nucleophilic addition to a polar pi bond when the nucleophile is weak is which of the following? a. A nucleophile addition b. A proton transfer to the nucleophile c. A proton transfer from the nucleophile d. A proton transfer to the carbonyl e. A proton transfer from the carbonyl
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7. For the following acid-base reaction, what statement is correct? A. B. C. CH₂FCH₂COOH + CH3CHFCOONa Acid Base فلات 11/22 ACHIC strong acid CH₂FCH₂COONa + CH3CHFCOOH C.B са CH₂FCH₂COOH is acid and left side of the equation is favored at equilibrium CH₂FCH₂COOH is conjugate acid and right side of the equation is favored at equilibrium Ht Acid -> Donate Base -> Accept Ht CH3CHFCOOH is acid and left side of the equation is favored at equilibrium CH3CHFCOOH is conjugate acid and right side of the equation is favored at equilibrium 28. 35