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When the compound I is replaced by compound II for anti-fungal activity, it was found that II has less side effects on the central nervous system (CNS) compared to I. The most likely explanation is: CI N. OH .CI II O The sulfur containing ring in I was easily converted into a toxic metabolite by the enzymes present in the CNS. O Replacement of Cl atoms by F leads to higher solubility in body fluids. O Il is more polar than I, hence it cannot cross the blood brain barrier easily. O The triazole rings in II is more bioorthogonal

When the compound I is replaced by compound II for anti-fungal activity, it was found that II has less side effects on the central nervous system (CNS) compared to I. The most likely explanation is: CI N. OH .CI II O The sulfur containing ring in I was easily converted into a toxic metabolite by the enzymes present in the CNS. O Replacement of Cl atoms by F leads to higher solubility in body fluids. O Il is more polar than I, hence it cannot cross the blood brain barrier easily. O The triazole rings in II is more bioorthogonal

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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When the compound I is replaced by compound II for anti-fungal activity, it was found that II has less side effects on the central nervous system (CNS) compared to I. The most likely explanation is: CI N. OH .CI II O The sulfur containing ring in I was easily converted into a toxic metabolite by the enzymes present in the CNS. O Replacement of Cl atoms by F leads to higher solubility in body fluids. O Il is more polar than I, hence it cannot cross the blood brain barrier easily. O The triazole rings in II is more bioorthogonal
Transcribed Image Text:When the compound I is replaced by compound II for anti-fungal activity, it was found that II has less side effects on the central nervous system (CNS) compared to I. The most likely explanation is: CI N. OH .CI II O The sulfur containing ring in I was easily converted into a toxic metabolite by the enzymes present in the CNS. O Replacement of Cl atoms by F leads to higher solubility in body fluids. O Il is more polar than I, hence it cannot cross the blood brain barrier easily. O The triazole rings in II is more bioorthogonal
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