Chang et al. in 2005 examined the association between a family history of hematopoietic cancer on an individual’s risk of lymphoma in Sweden. In this study, the investigators validated self-report of a family history by searching for family members’ diagnosis in the Swedish Cancer Registry and examined whether the validity of self-report differed between cases and controls. Use the information contained in the tables below to answer the accompany questions
Chang et al. in 2005 examined the association between a family history of hematopoietic cancer on an individual’s risk of lymphoma in Sweden. In this study, the investigators validated self-report of a family history by searching for family members’ diagnosis in the Swedish Cancer Registry and examined whether the validity of self-report differed between cases and controls. Use the information contained in the tables below to answer the accompany questions:
Assuming the following table displays the true distribution of exposure among cases and controls, construct a new table with misclassification of exposure if sensitivity and specificity are 60% and 98% among cases; and 38% and 99% among the controls respectively.
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True Distribution |
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Cases |
Control |
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Family history |
56.7 |
37.1 |
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No family history |
1148.3 |
1189.9 |
Compute the true ORT using the information from the table above.
Complete the observed or misclassified table below
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Observed / Misclassified Data |
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Cases |
Control |
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Family history |
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No family history |
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Compute the biased ORB using the information from the misclassified table.
From your opinion, what type of misclassification bias is this?
Compare the true ORT and the biased ORB.
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