Chang et al. in 2005 examined the association between a family history of hematopoietic cancer on an individual’s risk of lymphoma in Sweden. In this study, the investigators validated self-report of a family history by searching for family members’ diagnosis in the Swedish Cancer Registry and examined whether the validity of self-report differed between cases and controls. Use the information contained in the tables below to answer the accompany questions: Assuming the following table displays the true distribution of exposure among cases and controls, construct a new table with misclassification of exposure if sensitivity and specificity are 60% and 98% among cases; and 38% and 99% among the controls respectively. True Distribution Cases Control Family history 56.7 37.1 No family history 1148.3 1189.9 1. Compute the true ORT using the information from the table above. 2. Complete the observed or misclassified table below. Observed / Misclassified Data Cases Control Family history No family history 1. Compute the biased ORB using the information from the misclassified table. 2. From your opinion, what type of misclassification bias is this? 3. Compare the true ORT and the biased ORB
Chang et al. in 2005 examined the association between a family history of hematopoietic cancer on an individual’s risk of lymphoma in Sweden. In this study, the investigators validated self-report of a family history by searching for family members’ diagnosis in the Swedish Cancer Registry and examined whether the validity of self-report differed between cases and controls. Use the information contained in the tables below to answer the accompany questions:
Assuming the following table displays the true distribution of exposure among cases and controls, construct a new table with misclassification of exposure if sensitivity and specificity are 60% and 98% among cases; and 38% and 99% among the controls respectively.
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True Distribution |
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Cases |
Control |
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Family history |
56.7 |
37.1 |
|
No family history |
1148.3 |
1189.9 |
1. Compute the true ORT using the information from the table above.
2. Complete the observed or misclassified table below.
|
Observed / Misclassified Data |
||
|
|
Cases |
Control |
|
Family history |
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|
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No family history |
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1. Compute the biased ORB using the information from the misclassified table.
2. From your opinion, what type of misclassification bias is this?
3. Compare the true ORT and the biased ORB
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