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CH3 CH3 CpG island Core promoter CH3 CH3 CH3 Enhancer CpG island Core promoter CH, Chromatin in an open conformation A methyl-CpG-binding protein binds to the methylated CpG Island. Activator Coding sequence protein Methylation CH3 ÇH3 CH, CH, CH3 CH CH3 CH, CH CH CH сн, сн, сн, Methyl groups block the binding of an actvator protein to an enhancer element. Methyl-CpG- binding protein The methyl-CpG-binding protein recrults other proteins, such as histone deacetylase, that convert the chromatin to a closed conformation. Chromatin (a) Methylatlon Inhibits the binding of an activator proteln. In a dosed conformation CH, CH, CH, CH CH3 CH3 CH, Histone deacetylase (b) Methyl-CpG-binding proteln recrults other protelns that change the chromatin to a closed conformation.

CH3 CH3 CpG island Core promoter CH3 CH3 CH3 Enhancer CpG island Core promoter CH, Chromatin in an open conformation A methyl-CpG-binding protein binds to the methylated CpG Island. Activator Coding sequence protein Methylation CH3 ÇH3 CH, CH, CH3 CH CH3 CH, CH CH CH сн, сн, сн, Methyl groups block the binding of an actvator protein to an enhancer element. Methyl-CpG- binding protein The methyl-CpG-binding protein recrults other proteins, such as histone deacetylase, that convert the chromatin to a closed conformation. Chromatin (a) Methylatlon Inhibits the binding of an activator proteln. In a dosed conformation CH, CH, CH, CH CH3 CH3 CH, Histone deacetylase (b) Methyl-CpG-binding proteln recrults other protelns that change the chromatin to a closed conformation.

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Explain why the events shown in part (a) inhibit
transcription.

CH3 CH3 CpG island Core promoter CH3 CH3 CH3 Enhancer CpG island Core promoter CH, Chromatin in an open conformation A methyl-CpG-binding protein binds to the methylated CpG Island. Activator Coding sequence protein Methylation CH3 ÇH3 CH, CH, CH3 CH CH3 CH, CH CH CH сн, сн, сн, Methyl groups block the binding of an actvator protein to an enhancer element. Methyl-CpG- binding protein The methyl-CpG-binding protein recrults other proteins, such as histone deacetylase, that convert the chromatin to a closed conformation. Chromatin (a) Methylatlon Inhibits the binding of an activator proteln. In a dosed conformation CH, CH, CH, CH CH3 CH3 CH, Histone deacetylase (b) Methyl-CpG-binding proteln recrults other protelns that change the chromatin to a closed conformation.
Transcribed Image Text:CH3 CH3 CpG island Core promoter CH3 CH3 CH3 Enhancer CpG island Core promoter CH, Chromatin in an open conformation A methyl-CpG-binding protein binds to the methylated CpG Island. Activator Coding sequence protein Methylation CH3 ÇH3 CH, CH, CH3 CH CH3 CH, CH CH CH сн, сн, сн, Methyl groups block the binding of an actvator protein to an enhancer element. Methyl-CpG- binding protein The methyl-CpG-binding protein recrults other proteins, such as histone deacetylase, that convert the chromatin to a closed conformation. Chromatin (a) Methylatlon Inhibits the binding of an activator proteln. In a dosed conformation CH, CH, CH, CH CH3 CH3 CH, Histone deacetylase (b) Methyl-CpG-binding proteln recrults other protelns that change the chromatin to a closed conformation.
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