CF3 но. CF3 CHO Br Br H2N several NABH4 R3N steps HN-N aprepitant

Q: Reaction of X and phenylacetic acid forms an intermediate Y, which undergoes an intramolecular…

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Q: One step in the synthesis of sitaglipitin (Problem 17.14, a drug used to treat type 2 diabetes)…

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Q: Give the mechanisim? Ho

A: An arrow always depicts from a region of high electron density to low electron density ; that is…

Q: What carbonyl compound and diol are needed to prepare each compound?

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Q: The following intermediate was needed for the synthesis of tamoxifen, a widely used antiestrogen…

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Q: Draw a stepwise mechanism for the following reaction. CI AICI3

A: When the benzene reacts with an alkyl halide in the presence of a Lewis acid catalyst alkyl benzene…

Q: β-Vetivone is isolated from vetiver, a perennial grass that yields a variety ofcompounds used in…

A: Michael addition: The Michael addition begins with the removal of a proton from an ?,?-unsaturated…

Q: Draw a stepwise mechanism for the following reaction.

A: In the first step, the abstraction of proton takes place as follows:

Q: Draw compounds B and C from the following reaction scheme. excess CH3I Ag20, H20 heat A B

A: In presence of excess of CH3I followed by oxidation by silver oxide, amines undergo Hoffmann…

Organomagnesium compounds

The interaction of alkyl halide with Mg metal in a suitable ether solvent is the common method for the synthesis of the Grignard reagent.

Hydrolysis Grignard Reactions and Reduction

Organomagnesium halides are Grignard reagents. Francois Auguste Victor Grignard, a French chemist who received the Nobel Prize in Chemistry in 1912, created these highly useful reagents.