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CASE STUDY: Patient X, 3-year-old female came in because of difficulty of breathing. Condition started 4 days prior to admission when periorbital edema was noted which progressed and became generalized. Condition was associated with nonproductive cough & low-grade fever, relieved by Paracetamol. Three days. prior to admission, tea colored urine was noted. There was neither dysuria nor urinary frequency. Two days prior to admission, consult was sought with a private physician and was given Amoxicillin 53 mg/kg/day. Few hours PTA, patient was noted to be dyspneic hence consultation was sought at emergency room and subsequently admitted. Past Medical History: No previous admission. No allergic reaction. Family History: Denies of any heredofamilial diseases. Personal/Social History: Patient was delivered at home assisted by a hilot by NSVD with no complication. Breastfeeding was given until 11 months old and solids were started at 6 months. Immunization: Complete primary immunization Growth and Development: At par with age Physical Examination: CR: 140/min, RR: 58/min, T: 37 C • • BP: 140/100, Wt: 14 kg (75th percentile) • HEENT: with facial and periorbital edema with alar flaring, not tonsillopharyngeal congestion, no lymphadenopathy SKIN: no rashes: CHEST/LUNGS: no retractions, harsh breath sounds HEART: tachycardic, no murmur ADBOMEN: distended, positive fluid wave, liver and spleen not palpable EXREMITIES: with healed pyodermata scars on both lower extremities, grade 2 pitting bipedal edema. Case Discussion: 1. What is the possible diagnosis of the patient? 2. What are the significant features in the case? Why? 3. What complement is expected to be abnormal in this patient? 4. What is the pathophysiology of the disease causing the decreased level of complement? How many weeks do you expect the complement level would return to be normal? 5. Guide Questions: 1. Briefly discuss the 3 pathways of the complement system. 2. What are the functions of the complement system? 3. Enumerate the other soluble mediators of the immune system.

CASE STUDY: Patient X, 3-year-old female came in because of difficulty of breathing. Condition started 4 days prior to admission when periorbital edema was noted which progressed and became generalized. Condition was associated with nonproductive cough & low-grade fever, relieved by Paracetamol. Three days. prior to admission, tea colored urine was noted. There was neither dysuria nor urinary frequency. Two days prior to admission, consult was sought with a private physician and was given Amoxicillin 53 mg/kg/day. Few hours PTA, patient was noted to be dyspneic hence consultation was sought at emergency room and subsequently admitted. Past Medical History: No previous admission. No allergic reaction. Family History: Denies of any heredofamilial diseases. Personal/Social History: Patient was delivered at home assisted by a hilot by NSVD with no complication. Breastfeeding was given until 11 months old and solids were started at 6 months. Immunization: Complete primary immunization Growth and Development: At par with age Physical Examination: CR: 140/min, RR: 58/min, T: 37 C • • BP: 140/100, Wt: 14 kg (75th percentile) • HEENT: with facial and periorbital edema with alar flaring, not tonsillopharyngeal congestion, no lymphadenopathy SKIN: no rashes: CHEST/LUNGS: no retractions, harsh breath sounds HEART: tachycardic, no murmur ADBOMEN: distended, positive fluid wave, liver and spleen not palpable EXREMITIES: with healed pyodermata scars on both lower extremities, grade 2 pitting bipedal edema. Case Discussion: 1. What is the possible diagnosis of the patient? 2. What are the significant features in the case? Why? 3. What complement is expected to be abnormal in this patient? 4. What is the pathophysiology of the disease causing the decreased level of complement? How many weeks do you expect the complement level would return to be normal? 5. Guide Questions: 1. Briefly discuss the 3 pathways of the complement system. 2. What are the functions of the complement system? 3. Enumerate the other soluble mediators of the immune system.

Phlebotomy Essentials
Phlebotomy Essentials
6th Edition
ISBN:9781451194524
Author:Ruth McCall, Cathee M. Tankersley MT(ASCP)
Publisher:Ruth McCall, Cathee M. Tankersley MT(ASCP)
Chapter1: Phlebotomy: Past And Present And The Healthcare Setting
Section: Chapter Questions
Problem 1SRQ
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CASE STUDY: Patient X, 3-year-old female came in because of difficulty of breathing. Condition started 4 days prior to admission when periorbital edema was noted which progressed and became generalized. Condition was associated with nonproductive cough & low-grade fever, relieved by Paracetamol. Three days. prior to admission, tea colored urine was noted. There was neither dysuria nor urinary frequency. Two days prior to admission, consult was sought with a private physician and was given Amoxicillin 53 mg/kg/day. Few hours PTA, patient was noted to be dyspneic hence consultation was sought at emergency room and subsequently admitted. Past Medical History: No previous admission. No allergic reaction. Family History: Denies of any heredofamilial diseases. Personal/Social History: Patient was delivered at home assisted by a hilot by NSVD with no complication. Breastfeeding was given until 11 months old and solids were started at 6 months. Immunization: Complete primary immunization Growth and Development: At par with age Physical Examination: CR: 140/min, RR: 58/min, T: 37 C • • BP: 140/100, Wt: 14 kg (75th percentile) • HEENT: with facial and periorbital edema with alar flaring, not tonsillopharyngeal congestion, no lymphadenopathy SKIN: no rashes: CHEST/LUNGS: no retractions, harsh breath sounds HEART: tachycardic, no murmur ADBOMEN: distended, positive fluid wave, liver and spleen not palpable EXREMITIES: with healed pyodermata scars on both lower extremities, grade 2 pitting bipedal edema. Case Discussion: 1. What is the possible diagnosis of the patient? 2. What are the significant features in the case? Why? 3. What complement is expected to be abnormal in this patient? 4. What is the pathophysiology of the disease causing the decreased level of complement? How many weeks do you expect the complement level would return to be normal? 5. Guide Questions: 1. Briefly discuss the 3 pathways of the complement system. 2. What are the functions of the complement system? 3. Enumerate the other soluble mediators of the immune system.
Transcribed Image Text:CASE STUDY: Patient X, 3-year-old female came in because of difficulty of breathing. Condition started 4 days prior to admission when periorbital edema was noted which progressed and became generalized. Condition was associated with nonproductive cough & low-grade fever, relieved by Paracetamol. Three days. prior to admission, tea colored urine was noted. There was neither dysuria nor urinary frequency. Two days prior to admission, consult was sought with a private physician and was given Amoxicillin 53 mg/kg/day. Few hours PTA, patient was noted to be dyspneic hence consultation was sought at emergency room and subsequently admitted. Past Medical History: No previous admission. No allergic reaction. Family History: Denies of any heredofamilial diseases. Personal/Social History: Patient was delivered at home assisted by a hilot by NSVD with no complication. Breastfeeding was given until 11 months old and solids were started at 6 months. Immunization: Complete primary immunization Growth and Development: At par with age Physical Examination: CR: 140/min, RR: 58/min, T: 37 C • • BP: 140/100, Wt: 14 kg (75th percentile) • HEENT: with facial and periorbital edema with alar flaring, not tonsillopharyngeal congestion, no lymphadenopathy SKIN: no rashes: CHEST/LUNGS: no retractions, harsh breath sounds HEART: tachycardic, no murmur ADBOMEN: distended, positive fluid wave, liver and spleen not palpable EXREMITIES: with healed pyodermata scars on both lower extremities, grade 2 pitting bipedal edema. Case Discussion: 1. What is the possible diagnosis of the patient? 2. What are the significant features in the case? Why? 3. What complement is expected to be abnormal in this patient? 4. What is the pathophysiology of the disease causing the decreased level of complement? How many weeks do you expect the complement level would return to be normal? 5. Guide Questions: 1. Briefly discuss the 3 pathways of the complement system. 2. What are the functions of the complement system? 3. Enumerate the other soluble mediators of the immune system.
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