before addressing the q, let us first understand what neurofibromatosis is and what are its symptoms
neurofibromatoses [NF] are three genetically distinct disorders responsible for causing tumours of the nervous system.
the myelin sheath [supporting cells] is the major part that is damaged and results in a tumour and the ype of tumour depends on the type of supporting cells involved.
we have 3 distinct types of NFs, neurofibromatosis type 1 [NF1, von Recklinghaus disease], neurofibromatosis type 2 [NF2] and schwannomatosis
the symptoms of the 3 NFs are as follows:
|
NF1 |
NF2 |
schwannomatosis |
|
· café-au-lait” spots, ·two or more neurofibromas, · freckling in armpits or groins · Lisch nodules or iris hamartomas · optic nerve glioma and scoliosis
|
·bilateral vestibular schwannomas plus a unilateral vestibular schwannoma before age 30 · glioma,meningioma,schwannoma; or lenticular opacity (cataract) or juvenile cortical cataract |
· multiple schwannomas everywhere on the vestibular nerve. · Pain due to compressed nerves, · numbness, tingling, or weakness in the · do not have neurofibromas symptoms |
Step by step
Solved in 2 steps
