Calculate the degree of ionization of morphine, pKa 8.0, in a solution with a pH of 2.2. Predict how the degree of ionization could affect the ease of absorption of morphine in (a) the stomach and (b) the intestine when the pH of the stomach fluid is 2.0 and the pH of the intestinal fluid is 6.

Chemistry & Chemical Reactivity
10th Edition
ISBN:9781337399074
Author:John C. Kotz, Paul M. Treichel, John Townsend, David Treichel
Publisher:John C. Kotz, Paul M. Treichel, John Townsend, David Treichel
Chapter16: Principles Of Chemical Reactivity: The Chemistry Of Acids And Bases
Section: Chapter Questions
Problem 108GQ: The hydrogen phthalate ion, C8HsO4, is a weak acid with Ka = 3.91 106....
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Calculate the degree of ionization of morphine, pKa 8.0, in a solution with a pH of 2.2.
Predict how the degree of ionization could affect the ease of absorption of morphine in
(a) the stomach and (b) the intestine when the pH of the stomach fluid is 2.0 and the pH
of the intestinal fluid is 6.
Transcribed Image Text:Calculate the degree of ionization of morphine, pKa 8.0, in a solution with a pH of 2.2. Predict how the degree of ionization could affect the ease of absorption of morphine in (a) the stomach and (b) the intestine when the pH of the stomach fluid is 2.0 and the pH of the intestinal fluid is 6.
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