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(c) Peptide B had the following amino acid composition, obtained by acid hydrolysis and amino acid analysis. Arg, Ala, Gly, Leu, Lys, Pro, Ser, Tyr, Glu Treatment with trypsin gave tetrapeptide C-1 (Tyr, Glu, Ser, Gly) and pentapeptide C-2 (Lys, Pro, Ala, Arg, Leu). (i) Edman degradation of C-1 yielded Gly, then Tyr (ii) Edman degradation of C-2 yielded Ala, then Leu, then Arg Treatment of peptide B with chymotrypsin gave D-1 (Ala, Tyr, Gly, Arg, Lys, Pro, Leu) and D-2 (Ser, Glu). (i) (ii) Edman degradation of D-1 gave Ala in the first cycle, then Leu, then Arg. Edman degradation of D-2 gave Ser in the first cycle and Glu was remaining. Explain the above results. Give the sequence of peptide B?

(c) Peptide B had the following amino acid composition, obtained by acid hydrolysis and amino acid analysis. Arg, Ala, Gly, Leu, Lys, Pro, Ser, Tyr, Glu Treatment with trypsin gave tetrapeptide C-1 (Tyr, Glu, Ser, Gly) and pentapeptide C-2 (Lys, Pro, Ala, Arg, Leu). (i) Edman degradation of C-1 yielded Gly, then Tyr (ii) Edman degradation of C-2 yielded Ala, then Leu, then Arg Treatment of peptide B with chymotrypsin gave D-1 (Ala, Tyr, Gly, Arg, Lys, Pro, Leu) and D-2 (Ser, Glu). (i) (ii) Edman degradation of D-1 gave Ala in the first cycle, then Leu, then Arg. Edman degradation of D-2 gave Ser in the first cycle and Glu was remaining. Explain the above results. Give the sequence of peptide B?

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ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
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(c) Peptide B had the following amino acid composition, obtained by acid hydrolysis and amino acid analysis. Arg, Ala, Gly, Leu, Lys, Pro, Ser, Tyr, Glu Treatment with trypsin gave tetrapeptide C-1 (Tyr, Glu, Ser, Gly) and pentapeptide C-2 (Lys, Pro, Ala, Arg, Leu). (i) Edman degradation of C-1 yielded Gly, then Tyr (ii) Edman degradation of C-2 yielded Ala, then Leu, then Arg Treatment of peptide B with chymotrypsin gave D-1 (Ala, Tyr, Gly, Arg, Lys, Pro, Leu) and D-2 (Ser, Glu). (i) (ii) Edman degradation of D-1 gave Ala in the first cycle, then Leu, then Arg. Edman degradation of D-2 gave Ser in the first cycle and Glu was remaining. Explain the above results. Give the sequence of peptide B?
Transcribed Image Text:(c) Peptide B had the following amino acid composition, obtained by acid hydrolysis and amino acid analysis. Arg, Ala, Gly, Leu, Lys, Pro, Ser, Tyr, Glu Treatment with trypsin gave tetrapeptide C-1 (Tyr, Glu, Ser, Gly) and pentapeptide C-2 (Lys, Pro, Ala, Arg, Leu). (i) Edman degradation of C-1 yielded Gly, then Tyr (ii) Edman degradation of C-2 yielded Ala, then Leu, then Arg Treatment of peptide B with chymotrypsin gave D-1 (Ala, Tyr, Gly, Arg, Lys, Pro, Leu) and D-2 (Ser, Glu). (i) (ii) Edman degradation of D-1 gave Ala in the first cycle, then Leu, then Arg. Edman degradation of D-2 gave Ser in the first cycle and Glu was remaining. Explain the above results. Give the sequence of peptide B?
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