Brittany Hudson, 16 years of age, was seen by her physician after the development of a small pustule around her nostrils that had expanded and was now showing signs of ulceration typical of chronic granulomatous inflammation. In the previous year, Brittany had experienced a similar lesion on her left thigh that healed slowly, leaving a hyperpigmented scar. She also had a history of chronic bacterial infections of the upper and lower respiratory tract. Flow-cytometric analysis of peripheral blood revealed abnormally low numbers of MHC class I molecules on cell surfaces and abnormally low numbers of CD8 T cells. A diagnosis of type I bare lymphocyte syndrome was made. A deficiency in which of the following would explain this etiology? a. HLA-DM b. invariant chain c. class II-associated invariant chain peptide (CLIP) d. TAP-1 or TAP-2 e. MHC class II transactivator (CIITA).
Brittany Hudson, 16 years of age, was seen by her physician after the development of a small pustule around her nostrils that had expanded and was now showing signs of ulceration typical of chronic granulomatous inflammation. In the previous year, Brittany had experienced a similar lesion on her left thigh that healed slowly, leaving a hyperpigmented scar. She also had a history of chronic bacterial infections of the upper and lower respiratory tract. Flow-cytometric analysis of peripheral blood revealed abnormally low numbers of MHC class I molecules on cell surfaces and abnormally low numbers of CD8 T cells. A diagnosis of type I bare lymphocyte syndrome was made. A deficiency in which of the following would explain this etiology? a. HLA-DM b. invariant chain c. class II-associated invariant chain peptide (CLIP) d. TAP-1 or TAP-2 e. MHC class II transactivator (CIITA).
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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| Brittany Hudson, 16 years of age, was seen by her physician after the development of a small pustule around her nostrils that had expanded and was now showing signs of ulceration typical of chronic granulomatous inflammation. In the previous year, Brittany had experienced a similar lesion on her left thigh that healed slowly, leaving a hyperpigmented scar. She also had a history of chronic bacterial infections of the upper and lower respiratory tract. Flow-cytometric analysis of peripheral blood revealed abnormally low numbers of MHC class I molecules on cell surfaces and abnormally low numbers of CD8 T cells. A diagnosis of type I bare lymphocyte syndrome was made. A deficiency in which of the following would explain this etiology? |
| a. HLA-DM |
| b. invariant chain |
| c. class II-associated invariant chain peptide (CLIP) |
| d. TAP-1 or TAP-2 |
| e. MHC class II transactivator (CIITA). |
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