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bian olosrodonn-g.bioe oiosodomond-q bias oiosnsdonin B) Synthesize 3-hexanone using 1-propanol and any other reagents.

bian olosrodonn-g.bioe oiosodomond-q bias oiosnsdonin B) Synthesize 3-hexanone using 1-propanol and any other reagents.

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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**Synthesis of 3-Hexanone from 1-Propanol** *Objective:* B) Synthesize 3-hexanone using 1-propanol and any other reagents. *Procedure Overview:* To achieve the synthesis of 3-hexanone starting from 1-propanol, several chemical reactions can be employed. Here is a suggested pathway involving oxidation, oxidation, and aldol condensation: 1. **Oxidation of 1-Propanol:** - Convert 1-propanol to propanal using an oxidizing agent like PCC (Pyridinium chlorochromate). 2. **Aldol Condensation:** - React two equivalents of propanal in the presence of a base (e.g., NaOH) to form 3-hydroxyhexanal through aldol condensation. 3. **Dehydration:** - Dehydrate 3-hydroxyhexanal using an acid catalyst (e.g., H2SO4) to convert it to 3-hexenal. 4. **Hydrogenation:** - Finally, hydrogenate 3-hexenal to 3-hexanone using a hydrogenation catalyst like Pd/C in the presence of hydrogen gas. *Important Considerations:* - Ensure proper reaction conditions such as temperature and pH are maintained for each step. - Purify the final product using standard purification techniques like distillation or crystallization. This synthesis pathway provides a clear route from a simple alcohol to a more complex ketone, showcasing various organic chemistry techniques.
Transcribed Image Text:**Synthesis of 3-Hexanone from 1-Propanol** *Objective:* B) Synthesize 3-hexanone using 1-propanol and any other reagents. *Procedure Overview:* To achieve the synthesis of 3-hexanone starting from 1-propanol, several chemical reactions can be employed. Here is a suggested pathway involving oxidation, oxidation, and aldol condensation: 1. **Oxidation of 1-Propanol:** - Convert 1-propanol to propanal using an oxidizing agent like PCC (Pyridinium chlorochromate). 2. **Aldol Condensation:** - React two equivalents of propanal in the presence of a base (e.g., NaOH) to form 3-hydroxyhexanal through aldol condensation. 3. **Dehydration:** - Dehydrate 3-hydroxyhexanal using an acid catalyst (e.g., H2SO4) to convert it to 3-hexenal. 4. **Hydrogenation:** - Finally, hydrogenate 3-hexenal to 3-hexanone using a hydrogenation catalyst like Pd/C in the presence of hydrogen gas. *Important Considerations:* - Ensure proper reaction conditions such as temperature and pH are maintained for each step. - Purify the final product using standard purification techniques like distillation or crystallization. This synthesis pathway provides a clear route from a simple alcohol to a more complex ketone, showcasing various organic chemistry techniques.
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