Between your evening meal and breakfast, your blood glucose drops and your liver becomes a net producer rather than a consumer of glucose. Which statements describe the hormone-stimulated process that triggers glucose production by the liver? Epinephrine stimulates an enzyme cascade involving hepatic protein kinase A (PKA) and phosphorylase b kinase, which eventually leads to glycogen breakdown in the liver. The increase in [cAMP] causes protein kinase A to phosphorylate pyruvate kinase, thus inhibiting glycolysis in muscle tissue to promote gluconeogenesis in the liver. Glucagon stimulates cAMP-dependent phosphorylation of PFK-2/FBPase-2, which decreases [fructose 2,6-bisphosphate]. The rapid decrease in blood glucose levels triggers glucagon release by the pancreas. The decrease in [fructose 2,6-bisphosphate] stimulates FBPase-1, the key enzyme in gluconeogenesis. The decrease in [fructose 2,6-bisphosphate] stimulates PFK-1, the key enzyme in gluconeogenesis.

Between your evening meal and breakfast, your blood glucose drops and your liver becomes a net producer rather than a consumer of glucose. Which statements describe the hormone-stimulated process that triggers glucose production by the liver? Epinephrine stimulates an enzyme cascade involving hepatic protein kinase A (PKA) and phosphorylase b kinase, which eventually leads to glycogen breakdown in the liver. The increase in [cAMP] causes protein kinase A to phosphorylate pyruvate kinase, thus inhibiting glycolysis in muscle tissue to promote gluconeogenesis in the liver. Glucagon stimulates cAMP-dependent phosphorylation of PFK-2/FBPase-2, which decreases [fructose 2,6-bisphosphate]. The rapid decrease in blood glucose levels triggers glucagon release by the pancreas. The decrease in [fructose 2,6-bisphosphate] stimulates FBPase-1, the key enzyme in gluconeogenesis. The decrease in [fructose 2,6-bisphosphate] stimulates PFK-1, the key enzyme in gluconeogenesis.

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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