Benzodiazepines test device is a qualitative, preliminary test which would be able to detect whether Benzodiazepines are present in the urine specimen at the cut-off concentration of 300 ng/mL. Is it possible to have a urine specimen which was interpreted as POSITIVE using the Benzodiazepines test device to be interpreted as NEGATIVE by Gas Chromatography/Mass Spectrometry? Justify your answer. A study was conducted by the manufacturer of the benzodiazepines test device to determine whether some compounds would have cross-reactivity at levels of 100µg/mL. List down examples of non cross-reacting compounds

Benzodiazepines test device is a qualitative, preliminary test which would be able to detect whether Benzodiazepines are present in the urine specimen at the cut-off concentration of 300 ng/mL. Is it possible to have a urine specimen which was interpreted as POSITIVE using the Benzodiazepines test device to be interpreted as NEGATIVE by Gas Chromatography/Mass Spectrometry? Justify your answer. A study was conducted by the manufacturer of the benzodiazepines test device to determine whether some compounds would have cross-reactivity at levels of 100µg/mL. List down examples of non cross-reacting compounds

Biomedical Instrumentation Systems

1st Edition

ISBN:9781133478294

Author:Chatterjee

Publisher:Chatterjee

Chapter5: Biomedical Electronics: Digital

Section: Chapter Questions

Problem 5Q

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Which among the following statements is correct? O A positive result for Fohl's test is the formation of a black precipitate in the form of lead. O A positive result for Millon's test is characterized by the formation of a red-colored precipitate or solution. O Both statements are correct Both statements are incorrect
1. The Cocaine test device only provides a preliminary qualitative analytical result. The preferred confirmatory method for quantitating the concentration of Cocaine in the specimen is Gas Chromatography/ mass Spectrometry. After performing the screening test for Cocaine, 3 specimens were interpreted as POSITIVE and 10 specimens were interpreted as NEGATIVE. How many specimens will be sent for Confirmatory testing? Why? 2. This symbol was seen on the box containing the test devices for Cocaine. What does it mean? 3. Another symbol was seen on the box containing the test devices for Cocaine. What does it mean?
Choose the one answer that fits best. Which of the following statements regarding the proper procedure for using Micropipettes is NOT correct? O a. You cannot use a 2-20 µl micropipette to pipet 200 µl O b. To expel all the liquid from the tip, you have to press the eject button O c. To draw up solution, press and hold the plunger at the first stop before entering the solution O d. Micropipettes always require the use of a disposable plastic tip O e. While pipetting, micropipettes should always be held as straight as possible
A nurse reconstituted a vial of 750 mg Cefuroxime Sodium Powder for Injection with 6mL of sterile water for injection. The reconstituted solution was dark amber-colored solution. The package insert states that solution colors range from clear to yellow depending on concentration, diluent, and storage conditions. The nurse was then hesitant to give the patient the solution due to its unusual dark color. Five portions were taken from a batch of cefuroxime sodium. Prior to testing in the instrument, each part was subjected to one of the following conditions: Conditions Specifications Temperature Portion 1: 8°C ± 2°C Portion 2: 30°C ± 2°C Portion 3: 40°C ± 2°C Light Portion 4: Kept in the dark Portion 5: Exposed to direct sunlight 1. Which form of the product – the powder for injection, the reconstituted product, or both – will you subject to the following conditions? Why do you think these forms can best address the problem?
Paraphrase the text below: Series of test tubes were filled with the desired volume of the BSA (0.1, 0.2, 0.3… 1 ml) .PBS was added to this to make the volume of 1 mL. 5 mL of copper reagent was added to all the tubes. After proper mixing, all the tubes were incubated at room temperature for 15 minutes. 1 mL Folin reagent was added to each and mixed properly with the help of vortex mixer and incubated for 20 minutes. The intensity of the colour was then determined spectrophotometrically at 680 nm. The graph was than plotted between optical density and the amount of BSA. Proteins estimation was done for the detection for the amount of proteins present in the sample solutions by the Lowry method
A stool specimen from a 20-year-old man was sent to the Oregon State Public Health Laboratory for examination. An FEA (formalin-ethyl acetate) concentration was performed and wet mounts prepared for examination. The objects seen in the images were present in moderate numbers and ranged in size from 33 to 40 micrometers (Figures A and B). The specimen also contained several large objects that were forwarded to CDC for identification. The objects averaged 1 centimeter in length. The images show one of the submitted objects after clearing with lactophenol solution, before (Figure C) and after injecting with ink. What is your diagnosis? Based on what criteria? How does the patient acquire this infection? What is the infective stage? Introduce the pathogenesis of this infection briefly.
Would you expect the results from the MAC test to corroborate the results from the EMB test? Explain why or why not.
A Refractometer was used to test a patient's urine specimen. it has a current specific gravity reading of 1.045. The urine temperature is at 32 degrees Celsius and contains 2 g/dl of Glucose and 1 g/dI of Protein. What is the corrected specific gravity reading? A urine specimen was physically analyzed in the clinical laboratory. The clarity and color of the urine is clear red. Please explain in detail, the possible causes of the clear red appearance of the urine specimen and its simple disease correlation. A Urinometer was used to test a patient's urine specimen, it has a current specific gravity reading of 1.036. The urine temperature is at 29 degrees Celsius and contains 1 g/dl of Glucose. What is the corrected specific gravity reading?
A sample is diluted by a factor of 10 five times. The 10^-3 dilution has 272 colonies on it. Assuming you plated the same volume on each plate, how many colonies would you expect to find on the 10^-2 plate? Include units and use OCD formula.
For a simple routine qualitative analysis, why is an early morning sample of urine used for the tests, and not a sample collected after a meal? Explain briefly.
You need to make a 1/750 dilution of each human serum sample prior to testing it in your ELISA. You will need 1 ml of the diluted serum (which already includes extra for Murphy's Law.) Calculate the volume of undiluted human serum you need for your 1 ml test volume. 1.3 microliters O 13 microliters O 0.75 microliters O 7.3 microliters
6) 1 mL of supernatant is required for a procedure. The final colored solution proves to be too high to read accurately on the spectrophotometer. 100 μL of supernatant and 900 μL of distilled water are substituted for the original supernatant and the procedure, run as before. The reading from the standard curve is 46 mg/dL. What is the actual amount of substance in the patient serum?