Benzo(a)pyrene is a well known carcinogen. Based on its chemical properties, explain why benzo(a)pyrene and similar compounds are dangerous mutagens.
Benzo(a)pyrene is a well known carcinogen. Based on its chemical properties, explain why benzo(a)pyrene and similar compounds are dangerous mutagens.
Solution -
Benzo(a)pyrene -
Benzo[a]pyrene is a polycyclic aromatic hydrocarbon and the result of incomplete combustion of organic matter at temperatures between 300 °C and 600 °C. The ubiquitous compound can be found in coal tar, tobacco smoke and many foods, especially grilled meats
The PAH prototype benzo[a]pyrene (B[a]P), an AhR ligand, exhibits a strong carcinogenic potential and it is classified as a carcinogen to humans by the International Agency for Research on Cancer (IARC).
However, the effects of B[a]P and of PAHs more generally, on cell energy metabolism are not well known
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