Below you will see a wedge-dash diagram, and an incomplete Newman projection with the designated bond you are looking down. Your task is to complete the Newman projection, by filling-in each box below, with the substituents (e.g. CH3, Br, H, etc. - whichever substituents remain in the molecule) that would give the MOST STABLE conformer. CH₂ 1: 2: 3: 4: CH₂ 1 H₂C CH(CH₂)₂ 2 3 Looking down C4-C3 bond 4

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Chapter1: Chemical Foundations
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## Stereochemistry

### Determine the Stereochemistry Configuration

Consider the molecule given below. Assign the R or S configuration for each of the chiral centers.

#### Molecules and Diagram Description:

**Molecule 1**: 
```
    CH3
     |
H3C--C--CH2OH
     |
     H
```
**Molecule 2**: 
```
    CH3
     |
HO--C--CH3
     |
     H
```

**Instructions**: 
Using the wedge-and-dash diagram of the molecule, fill in the boxes for the most stable conformer. Provide the configuration for the highlighted chiral centers by looking down the C4-C3 axis and filling in with the substituents like H, CH₃, OH, etc. 

**Boxes**:
```
4:  ________  

3:  ________  

2:  ________  
 
1:  ________  
```

The graphical diagram illustrates two molecules with chiral centers. The visualization emphasizes the need to determine the R/S configuration of each stereogenic center by analyzing the substituents connected to them.

---

#### Explanation:

- To assign an R or S configuration to a chiral center:
  1. Identify the four different substituents attached to the chiral carbon.
  2. Assign priorities (1 to 4) based on atomic numbers, with 1 being the highest priority.
  3. Orient the molecule so that the lowest priority group (4) is pointing away from you.
  4. Observe the sequence from 1 to 3. If it goes clockwise, the configuration is R. If counterclockwise, it is S.

---

Complete this exercise by analyzing each molecule's chiral centers and noting the R/S configuration in the boxes provided.
Transcribed Image Text:## Stereochemistry ### Determine the Stereochemistry Configuration Consider the molecule given below. Assign the R or S configuration for each of the chiral centers. #### Molecules and Diagram Description: **Molecule 1**: ``` CH3 | H3C--C--CH2OH | H ``` **Molecule 2**: ``` CH3 | HO--C--CH3 | H ``` **Instructions**: Using the wedge-and-dash diagram of the molecule, fill in the boxes for the most stable conformer. Provide the configuration for the highlighted chiral centers by looking down the C4-C3 axis and filling in with the substituents like H, CH₃, OH, etc. **Boxes**: ``` 4: ________ 3: ________ 2: ________ 1: ________ ``` The graphical diagram illustrates two molecules with chiral centers. The visualization emphasizes the need to determine the R/S configuration of each stereogenic center by analyzing the substituents connected to them. --- #### Explanation: - To assign an R or S configuration to a chiral center: 1. Identify the four different substituents attached to the chiral carbon. 2. Assign priorities (1 to 4) based on atomic numbers, with 1 being the highest priority. 3. Orient the molecule so that the lowest priority group (4) is pointing away from you. 4. Observe the sequence from 1 to 3. If it goes clockwise, the configuration is R. If counterclockwise, it is S. --- Complete this exercise by analyzing each molecule's chiral centers and noting the R/S configuration in the boxes provided.
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