Below is one of the steps in the synthesis. What type of reaction is it? Br , AICI, он Niraparib • RT Br 5 °C Bromination O Friedel Crafts alkylation Friedel Crafts acylation O Nucleophilic Acyl Substitution

Below is one of the steps in the synthesis. What type of reaction is it? Br , AICI, он Niraparib • RT Br 5 °C Bromination O Friedel Crafts alkylation Friedel Crafts acylation O Nucleophilic Acyl Substitution

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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Question

Below is the structure of Niraparib (Zejula®), a drug used in recurrent ovarian
cancer.
H
N-
EN
H2N
Niraparib Zejula®
Below is one of the steps in the synthesis. What type of reaction is it?
Br
AIC,
OH
Niraparib
5 °C
> RT
Br
O Bromination
O Friedel Crafts alkylation
O Friedel Crafts acylation
O Nucleophilic Acyl Substitution

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