(b) What is the ratio of fumarate to malate under cellular conditions at 37°C? Is this reaction likely to be a control point for the citric acid cycle? Explain. The AGº for the fumarase reaction is -3.4 kJ/mol but the AG value is close to zero.
(b) What is the ratio of fumarate to malate under cellular conditions at 37°C? Is this reaction likely to be a control point for the citric acid cycle? Explain. The AGº for the fumarase reaction is -3.4 kJ/mol but the AG value is close to zero.
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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I need help with part B
Transcribed Image Text:5. (a)
citrate synthase:
Citrate is formed by the condensation of acetyl-CoA with oxaloacetate, catalyzed by
Охaloacetatе
acetyl-CoA
H2O →
citrate + CoA
+ H+
+
+
In rat heart mitochondria at pH 7.0 and 25 °C, the conditions of reactants and products are as follows:
oxaloacetate, 1 µM; acetyl-CoA, 1 µM; citrate, 220 µM and CoA, 65 µM . The standard free-energy
change for the citrate synthase reaction is – 32.2 kJ/mol. What is the direction of metabolite flow through
the citrate synthase reaction in rat heart cells under the concentrations of reactants and products given?
The AG° for the fumarase reaction is -3.4 kJ/mol but the AG value is close to zero.
(b)
What is the ratio of fumarate to malate under cellular conditions at 37°C? Is this reaction likely to
be a control point for the citric acid cycle? Explain.
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