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Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Macmillan Learning
Each ionizable group of an amino acid can exist in one of two states, charged or neutral. The electric charge on the functional
group is determined by the relationship between its pK, and the pH of the solution. This relationship is described by the
Henderson-Hasselbalch equation.
Histidine has three ionizable functional groups. Complete the equilibrium equations by assigning the proper pK, for each
ionization and the net charge on the histidine molecule in each ionization state.
O
H ||
H₂N-C-C-OH
CH₂
+
HN
-NH
PK₂=9.17
H
H₂N-C-
HN
PK₁=7.59
CH₂
-NH
-0-
Answer Bank
pk,= 1.8
+2
O
H-L
H₂N-C-C-O
CH₂
-NH
PK, = 6.0
-2
H
H₂N-C-C-O
1
CH₂
+1
-NH
0
Transcribed Image Text:Macmillan Learning Each ionizable group of an amino acid can exist in one of two states, charged or neutral. The electric charge on the functional group is determined by the relationship between its pK, and the pH of the solution. This relationship is described by the Henderson-Hasselbalch equation. Histidine has three ionizable functional groups. Complete the equilibrium equations by assigning the proper pK, for each ionization and the net charge on the histidine molecule in each ionization state. O H || H₂N-C-C-OH CH₂ + HN -NH PK₂=9.17 H H₂N-C- HN PK₁=7.59 CH₂ -NH -0- Answer Bank pk,= 1.8 +2 O H-L H₂N-C-C-O CH₂ -NH PK, = 6.0 -2 H H₂N-C-C-O 1 CH₂ +1 -NH 0
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